现代医药卫生
現代醫藥衛生
현대의약위생
MODERN MEDICINE HEALTH
2014年
16期
2420-2421
,共2页
肝病%胆固醇%总胆汁酸%肝功能分级
肝病%膽固醇%總膽汁痠%肝功能分級
간병%담고순%총담즙산%간공능분급
Liver diseases(TCM)%Cholesterol%Total bile acid%Child-pugh
目的：探讨肝病患者血清总胆固醇（TC）、总胆汁酸（TBA）检测的临床意义。方法选择2012年2月至2013年10月在该院确诊为肝硬化的86例患者设为肝硬化组，确诊为肝癌的84例患者设为肝癌组，另选择80例同期健康体检者设为对照组，检测血清TC与TBA水平，对三组检测结果进行统计学分析。结果与对照组比较，肝硬化组和肝癌组血清TC水平明显降低，差异有统计学意义（P<0.05），而TBA水平明显升高，差异有统计学意义（P<0.05）；在肝硬化组Child-Pugh分级中，C级患者的血清TC水平最低，分别与A级和B级两两比较，差异均有统计学意义（P<0.05），但A级与B级比较，差异无统计学意义（P＞0.05）；血清TBA在肝硬化组的A、B、C级中两两比较，差异均有统计学意义（P<0.05），且其水平随着肝功能Child-Pugh分级的增高而升高。结论肝病患者TC、TBA水平均能敏感反映肝损伤的进展情况，是诊断肝病的良好指标，2项指标联合检测可以提高肝硬化疾病的灵敏度，降低漏诊率。
目的：探討肝病患者血清總膽固醇（TC）、總膽汁痠（TBA）檢測的臨床意義。方法選擇2012年2月至2013年10月在該院確診為肝硬化的86例患者設為肝硬化組，確診為肝癌的84例患者設為肝癌組，另選擇80例同期健康體檢者設為對照組，檢測血清TC與TBA水平，對三組檢測結果進行統計學分析。結果與對照組比較，肝硬化組和肝癌組血清TC水平明顯降低，差異有統計學意義（P<0.05），而TBA水平明顯升高，差異有統計學意義（P<0.05）；在肝硬化組Child-Pugh分級中，C級患者的血清TC水平最低，分彆與A級和B級兩兩比較，差異均有統計學意義（P<0.05），但A級與B級比較，差異無統計學意義（P＞0.05）；血清TBA在肝硬化組的A、B、C級中兩兩比較，差異均有統計學意義（P<0.05），且其水平隨著肝功能Child-Pugh分級的增高而升高。結論肝病患者TC、TBA水平均能敏感反映肝損傷的進展情況，是診斷肝病的良好指標，2項指標聯閤檢測可以提高肝硬化疾病的靈敏度，降低漏診率。
목적：탐토간병환자혈청총담고순（TC）、총담즙산（TBA）검측적림상의의。방법선택2012년2월지2013년10월재해원학진위간경화적86례환자설위간경화조，학진위간암적84례환자설위간암조，령선택80례동기건강체검자설위대조조，검측혈청TC여TBA수평，대삼조검측결과진행통계학분석。결과여대조조비교，간경화조화간암조혈청TC수평명현강저，차이유통계학의의（P<0.05），이TBA수평명현승고，차이유통계학의의（P<0.05）；재간경화조Child-Pugh분급중，C급환자적혈청TC수평최저，분별여A급화B급량량비교，차이균유통계학의의（P<0.05），단A급여B급비교，차이무통계학의의（P＞0.05）；혈청TBA재간경화조적A、B、C급중량량비교，차이균유통계학의의（P<0.05），차기수평수착간공능Child-Pugh분급적증고이승고。결론간병환자TC、TBA수평균능민감반영간손상적진전정황，시진단간병적량호지표，2항지표연합검측가이제고간경화질병적령민도，강저루진솔。
Objective To explore the clinical significance of the detection of serum total choesterol (TC) and total bile acid(TBA) for hepatopath. Methods A total of 86 patients,who were diagnosed with cirrhosis from February 2012 to October 2013,were selected as cirrhosis group,simultaneously,other 84 patients diagnosed with liver cancer were taken as cancer group, and other 70 healthy subjects were chosen as control group. To detect the levels of serum TC and TBA ,and the results of the three groups were analyzed statistically. Results Compared with the control group,the serum TC level reduced apparently in both cir-rhosis group and cancer group with statistically significant difference (P<0.05),but serum TBA level increased obviously with statis-tically significant difference(P<0.05). According to Child-Pugh classification in cirrhosis group,the serum TC in the patients with Grade C was the lowest,which compared with the Grade A and Grade B respectively,the differenced showed statistical signifi-cance(P<0.05),but the difference between Grade A and Grade B had no statistical significance (P>0.05);moreover,pairwise com panison of serum TBA level among Grade A,Grade B and Grade C in cirrhosis group had statistically significant difference(P<0.05), and the level of serum TBA showed upward tendency with the increase of Child-Pugh classification. Conclusion The levels of TBA and TC in hepatopathy are helpful to reflect the state of liver damage ,they are both good indicators for diagnosis of liver dis-ease,in addition,the joint detection of TC and TBA can improve the sensitivity of cirrhosis ,reduce the rate of missed diagnosis.
