CAJ | 학술논문

目的：探讨苹果酸法米替尼联合同步放化疗治疗鼻咽癌患者不良反应及总结护理要点。方法对本院2011年11月～2013年12月20例局部晚期鼻咽癌患者采用苹果酸法米替尼联合同步放化疗，观察治疗过程患者不良反应发生情况及发生时间，并给予针对性对症处理。结果高血压、肾毒性、口腔黏膜炎、骨髓抑制、消化道反应、鼻出血、肝功能异常和手足皮肤反应发生率分别为60.0%、70.0%、90.0%、100.0%、85.0%、10.0%、45.0%和25.0%，给予对症处理后均能顺利完成治疗。结论苹果酸法米替尼联合同步放化疗治疗晚期鼻咽癌患者不良反应发生率较高，用药过程严密观察和监测患者用药后发生不良反应情况，及时处理，其可确保患者顺利完成治疗过程。
목적：탐토평과산법미체니연합동보방화료치료비인암환자불량반응급총결호리요점。방법대본원2011년11월～2013년12월20례국부만기비인암환자채용평과산법미체니연합동보방화료，관찰치료과정환자불량반응발생정황급발생시간，병급여침대성대증처리。결과고혈압、신독성、구강점막염、골수억제、소화도반응、비출혈、간공능이상화수족피부반응발생솔분별위60.0%、70.0%、90.0%、100.0%、85.0%、10.0%、45.0%화25.0%，급여대증처리후균능순리완성치료。결론평과산법미체니연합동보방화료치료만기비인암환자불량반응발생솔교고，용약과정엄밀관찰화감측환자용약후발생불량반응정황，급시처리，기가학보환자순리완성치료과정。
Objective To investigate effect of famitinib malate on adverse reactions by radiotherapy and chemotherapy in treatment of advanced nasopharyngeal carcinoma and the nursing strategies.Methods From November 2011 to December 2013, 20 cases of advanced nasopharyngeal carcinoma in our hospital were treated with famitinib malate combined with radiotherapy and chemotherapy.During the treatment,we observed the adverse reactions and gave the symptomatic treatment.Results The rates of adverse reactions such as hypertension,renal toxicity,oral mucositis,myelosuppression,gastrointestinal reactions,nasal bleeding, abnormal liver function,and hand-foot skin reaction were 60.0%,70.0%,90.0%,100.0%,85.0%,10.0%,45.0%and 25.0%respectively.After symptomatic treatment,all completed the treatment.Conclusions The incidence rate of adverse reactions of famitinib malate combined with radiotherapy and chemotherapy for treating advanced nasopharyngeal carcinoma is high.Close monitoring and observation during treatment courses can ensure the successful completion of treatment.