CAJ | 학술논문

目的：观察磷酸肌酸钠对早产儿缺氧缺血性心肌损伤的疗效。方法选择该院2009年7月至2011年11月收治的因窒息引起的心肌损伤早产儿104例，随机分为治疗组（56例）和对照组（48例），两组早产儿均给予常规治疗。治疗组在常规治疗的基础上给予磷酸肌酸钠0.5 g/d；对照组予维生素C 100 mg/kg，每天1次，1个疗程后（10 d）观察治疗前、后肌酸激酶（CK）、肌酸激酶同工酶（CK-MB）、心肌肌钙蛋白I（cTnI）的变化。结果治疗组早产儿治疗后CK、CK-MB和cTnI水平较对照组明显降低，差异均有统计学意义（P＜0.05）。结论磷酸肌酸钠治疗早产儿缺氧缺血性心肌损伤有效。
목적：관찰린산기산납대조산인결양결혈성심기손상적료효。방법선택해원2009년7월지2011년11월수치적인질식인기적심기손상조산인104례，수궤분위치료조（56례）화대조조（48례），량조조산인균급여상규치료。치료조재상규치료적기출상급여린산기산납0.5 g/d；대조조여유생소C 100 mg/kg，매천1차，1개료정후（10 d）관찰치료전、후기산격매（CK）、기산격매동공매（CK-MB）、심기기개단백I（cTnI）적변화。결과치료조조산인치료후CK、CK-MB화cTnI수평교대조조명현강저，차이균유통계학의의（P＜0.05）。결론린산기산납치료조산인결양결혈성심기손상유효。
Objective To observe the effect of creatine phosphate sodium on premature infants with hypoxic ischemic myocardial injury. Methods A total of 104 premature infants with hypoxic ischemic myocardial injury,who were in the hospital from June 2009 to November 2011,were randomized into treatment group(n=56)and control group(n=48). Based on the conven-tional therapy,the treatment group was added with creatine phosphate sodium,0.5 g daily;the control group was added with vita min C 100 mg/kg,once daily. After a course of treatment(10 d),the changes of creatine kinase(CK),CK-MB and cardiac tro-poninI(cTnI) in both groups were observed. Results After treatment,the levels of CK,CK-MB and cTnI of the premature infants in the treatment group reduced more obviously than those in the control group ,and the difference was statistically significant (P<0.05). Conclusion Creatine phosphate sodium is effective for the treatment of premature infants with hypoxic ischemic myocar-dial damage.