现代医药卫生
現代醫藥衛生
현대의약위생
MODERN MEDICINE HEALTH
2014年
17期
2587-2588,2590
,共3页
阮寒光%吴永华%邬蒙
阮寒光%吳永華%鄔矇
원한광%오영화%오몽
铂%输注,静脉内%癌,非小细胞肺%老年人%毒性作用
鉑%輸註,靜脈內%癌,非小細胞肺%老年人%毒性作用
박%수주,정맥내%암,비소세포폐%노년인%독성작용
Platinum%Infusions,intravenous%Carcinoma,non-small-cell lung%Aged%Toxic actions
目的:观察多西他赛(TAX)和洛铂(LBP)组成的TL化疗方案治疗老年晚期非小细胞肺癌(NSCLC)的疗效和毒性反应。方法选择2011年1月至2012年12月南昌市第三医院采用TL(TAX联合LBP)化疗方案治疗的26例老年晚期NSCLC患者,将TAX 75 mg/m2溶于生理盐水250 mL或5%葡萄糖溶液250 mL中,静脉滴注1 h;另将LBP 30 mg/m2溶于5%葡萄糖溶液250 mL中,静脉滴注3 h;3周为1个周期。结果所有患者中无一例完全缓解,获部分缓解4例(15.4%),稳定13例(50.0%),进展9例(34.6%),有效率为15.4%,肿瘤控制率为65.4%;主要毒性反应为骨髓抑制,尤以血小板减少为重,未发现明显的肾功能损伤。结论 TAX联合LBP治疗老年晚期NSCLC的疗效较好,但临床上采用该方案治疗的同时应加强血细胞监测及造血因子支持。
目的:觀察多西他賽(TAX)和洛鉑(LBP)組成的TL化療方案治療老年晚期非小細胞肺癌(NSCLC)的療效和毒性反應。方法選擇2011年1月至2012年12月南昌市第三醫院採用TL(TAX聯閤LBP)化療方案治療的26例老年晚期NSCLC患者,將TAX 75 mg/m2溶于生理鹽水250 mL或5%葡萄糖溶液250 mL中,靜脈滴註1 h;另將LBP 30 mg/m2溶于5%葡萄糖溶液250 mL中,靜脈滴註3 h;3週為1箇週期。結果所有患者中無一例完全緩解,穫部分緩解4例(15.4%),穩定13例(50.0%),進展9例(34.6%),有效率為15.4%,腫瘤控製率為65.4%;主要毒性反應為骨髓抑製,尤以血小闆減少為重,未髮現明顯的腎功能損傷。結論 TAX聯閤LBP治療老年晚期NSCLC的療效較好,但臨床上採用該方案治療的同時應加彊血細胞鑑測及造血因子支持。
목적:관찰다서타새(TAX)화락박(LBP)조성적TL화료방안치료노년만기비소세포폐암(NSCLC)적료효화독성반응。방법선택2011년1월지2012년12월남창시제삼의원채용TL(TAX연합LBP)화료방안치료적26례노년만기NSCLC환자,장TAX 75 mg/m2용우생리염수250 mL혹5%포도당용액250 mL중,정맥적주1 h;령장LBP 30 mg/m2용우5%포도당용액250 mL중,정맥적주3 h;3주위1개주기。결과소유환자중무일례완전완해,획부분완해4례(15.4%),은정13례(50.0%),진전9례(34.6%),유효솔위15.4%,종류공제솔위65.4%;주요독성반응위골수억제,우이혈소판감소위중,미발현명현적신공능손상。결론 TAX연합LBP치료노년만기NSCLC적료효교호,단림상상채용해방안치료적동시응가강혈세포감측급조혈인자지지。
Objective To study the toxicity and efficacy of chemotherapy with docetaxel (TAX) combined with lobaplatin (LBP) for elderly patients with advanced non-small cell lung cancer(NSCLC). Methods From January 2011 to December 2012,26 elderly patients with advanced NSCLC were treated with TL(TAX combined with LBP) for chemotherapy regimens. TAX 75 mg/m2 was dissolved in 250 mL normal saline(NS) or 250 mL 5%glucose solution for 1-h intravenous drip;LBP 30 mg/m2 was dissolved in 250 mL 5%glucose solution for 3-h intravenous drip. 3 weeks was taken as a period. Results Among the 26 pa-tients,4 cases got partial remission(15.4%),13 cases got stable(50.0%) and 9 cases got progressive(34.6%) with the effective rate of 15.4%and disease control rate of 65.4%. The main toxicities were myelosuppression ,especially thrombocytopenia. Serious renal toxicity did not appeared. Conclusion This combination therapy of TAX and LBP has good effect for elderly patients with advanced NSCLC,but hematopoietic factor support should be strengthened when the therapy is adopted in clinic.