山东医药
山東醫藥
산동의약
SHANDONG MEDICAL JOURNAL
2014年
38期
22-25
,共4页
三阴性乳腺癌%基质细胞衍生因子-1%基质细胞衍生因子受体-4%无瘤生存
三陰性乳腺癌%基質細胞衍生因子-1%基質細胞衍生因子受體-4%無瘤生存
삼음성유선암%기질세포연생인자-1%기질세포연생인자수체-4%무류생존
triple negative breast cancer%stromal cell derived factor-1%cell derived factor receptor-4%disease free survival
目的：探讨基质细胞衍生因子-1（SDF-1）及基质细胞衍生因子受体-4（CXCR4）在三阴性乳腺癌（TNBC）组织中的表达和临床意义。方法用免疫组化法检测77例TNBC组织中SDF-1和CXCR4的表达，分析SDF-1和CXCR4与TNBC临床病理特征及患者预后的关系。结果 SDF-1和CXCR4在TNBC中高表达率分别为41．6％、64．9％，且二者表达呈显著正相关（P＝0．041）；SDF-1和CXCR4高表达与患者年龄、肿瘤大小、临床分期及组织学分级不相关（P＞0．05），与淋巴结转移及无瘤生存呈显著正相关；多因素分析结果表明：SDF-1是TNBC患者无瘤生存的独立预后因素（ OR＝2．318，95％CI＝1．028～5．230）。生存分析显示SDF-1和CXCR4高表达者无瘤生存时间短于低表达者（P均＜0．05）。结论 TNBC中SDF-1／CXCR4表达可作为判断TNBC预后的重要生物学指标。
目的：探討基質細胞衍生因子-1（SDF-1）及基質細胞衍生因子受體-4（CXCR4）在三陰性乳腺癌（TNBC）組織中的錶達和臨床意義。方法用免疫組化法檢測77例TNBC組織中SDF-1和CXCR4的錶達，分析SDF-1和CXCR4與TNBC臨床病理特徵及患者預後的關繫。結果 SDF-1和CXCR4在TNBC中高錶達率分彆為41．6％、64．9％，且二者錶達呈顯著正相關（P＝0．041）；SDF-1和CXCR4高錶達與患者年齡、腫瘤大小、臨床分期及組織學分級不相關（P＞0．05），與淋巴結轉移及無瘤生存呈顯著正相關；多因素分析結果錶明：SDF-1是TNBC患者無瘤生存的獨立預後因素（ OR＝2．318，95％CI＝1．028～5．230）。生存分析顯示SDF-1和CXCR4高錶達者無瘤生存時間短于低錶達者（P均＜0．05）。結論 TNBC中SDF-1／CXCR4錶達可作為判斷TNBC預後的重要生物學指標。
목적：탐토기질세포연생인자-1（SDF-1）급기질세포연생인자수체-4（CXCR4）재삼음성유선암（TNBC）조직중적표체화림상의의。방법용면역조화법검측77례TNBC조직중SDF-1화CXCR4적표체，분석SDF-1화CXCR4여TNBC림상병리특정급환자예후적관계。결과 SDF-1화CXCR4재TNBC중고표체솔분별위41．6％、64．9％，차이자표체정현저정상관（P＝0．041）；SDF-1화CXCR4고표체여환자년령、종류대소、림상분기급조직학분급불상관（P＞0．05），여림파결전이급무류생존정현저정상관；다인소분석결과표명：SDF-1시TNBC환자무류생존적독립예후인소（ OR＝2．318，95％CI＝1．028～5．230）。생존분석현시SDF-1화CXCR4고표체자무류생존시간단우저표체자（P균＜0．05）。결론 TNBC중SDF-1／CXCR4표체가작위판단TNBC예후적중요생물학지표。
Objective To investigate the expression and clinical significance of stromal cell derived factor-1 ( SDF-1) and its receptor stromal cell derived factor receptor-4 ( CXCR4) in triple negative breast cancer( TNBC) tissue.Methods The expression of SDF-1 and CXCR4 of 77 TNBC cases were detected by using immunohistochemistry.The correlation between SDF-1/CXCR and clinical pathological features and prognosis were assessed.Results The expression rate of SDF-1 and CXCR4 in TNBC tissues was 41.6%, 64.9%, respectively.The expression rate of SDF-1 and CXCR4 in TN-BC tissues were significantly correlated (P=0.041).The high expression of SDF-1 and CXCR4 were not correlated with age, tumor size, clinical stage and histological grade(P>0.05), but obviously correlated with lymph node metastasis(PS-DF-1=0.021,PCXCR4=0.010) and disease free survival(PSDF-1=0.023,PCXCR4=0.015).COX regression multi-variate analysis showed that SDF-1 was an independent prognostic factor of disease free survival in TNBC(OR=2.318, 95%CI=1.028-5.230).Kaplan-Meier survival analysis indicated that time of disease free survival was shorter in SDF-1 and CXCR4 high expression patients than that in low expression patients(PSDF-1=0.011,PCXCR4=0.018).Conclu-sions The expression of SDF-1 and CXCR4 in TNBC tissues can be used as important biomarkers of the prognosis.
