CAJ | 학술논문

目的：检测妊娠期糖尿病（ GDM）孕妇与正常健康孕妇血浆及脐血中网膜素1的水平，探讨其在GDM发病过程中的作用及其与胰岛素抵抗的相关性。方法选取GDM孕妇39例为GDM组，正常健康孕妇44例为NGT组。根据孕妇孕前的体质量指数（ BMI ）将上述2组分为体质量正常组和肥胖组，用酶联免疫吸附（ ELISA ）方法测定血浆及脐血中网膜素1的浓度、空腹血糖（ FBG）、空腹胰岛素（ FINS）、OGTT后1 h血糖及2 h血糖，计算胰岛素抵抗指数（ HOMA-IR）。结果 GDM肥胖组网膜素1水平明显低于GDM体质量正常组（ P＜0．01）；GDM体质量正常组孕妇血浆网膜素1水平明显低于NGT体质量正常组（ P＜0．01）；GDM组孕妇血中胰岛素、血糖、HOMA-IR与NGT组比较差异有统计学意义（P均＜0．05）；孕妇网膜素1浓度与孕妇BMI、FBG、FINS、OGTT后1 h血糖水平、HOMA-IR呈显著负相关性（P＜0．05）。孕妇及脐血网膜素1与新生儿出生体质量无明显相关性。结论 GDM孕妇尤为肥胖者血清网膜素1水平下降，可能为早期检测GDM提供一种新的方法。
목적：검측임신기당뇨병（ GDM）잉부여정상건강잉부혈장급제혈중망막소1적수평，탐토기재GDM발병과정중적작용급기여이도소저항적상관성。방법선취GDM잉부39례위GDM조，정상건강잉부44례위NGT조。근거잉부잉전적체질량지수（ BMI ）장상술2조분위체질량정상조화비반조，용매련면역흡부（ ELISA ）방법측정혈장급제혈중망막소1적농도、공복혈당（ FBG）、공복이도소（ FINS）、OGTT후1 h혈당급2 h혈당，계산이도소저항지수（ HOMA-IR）。결과 GDM비반조망막소1수평명현저우GDM체질량정상조（ P＜0．01）；GDM체질량정상조잉부혈장망막소1수평명현저우NGT체질량정상조（ P＜0．01）；GDM조잉부혈중이도소、혈당、HOMA-IR여NGT조비교차이유통계학의의（P균＜0．05）；잉부망막소1농도여잉부BMI、FBG、FINS、OGTT후1 h혈당수평、HOMA-IR정현저부상관성（P＜0．05）。잉부급제혈망막소1여신생인출생체질량무명현상관성。결론 GDM잉부우위비반자혈청망막소1수평하강，가능위조기검측GDM제공일충신적방법。
Objective It is to determine the level of omentin 1 in the patients with gestational diabetes mellitus ( GDM) and normal healthy pregnant women , and to explore its effect in the development of GDM and its relationship with insulin re-sistance .Methods 39 pregnant women with GDM were selected as GDM group and 44 healthy pregnant subjects were selected as NGT group .According to BMI of the women before pregnancy the two groups were divided into obese group and normal weight group.The content of omentin 1, FBG, FINS, 1 h BG and 2 h BG after OGTT were determined by ELISA, and HOMA-IR was calculated .Results The level of omentin 1 in GDM obese group was significantly lower than that in GDM normal weight group (P<0.01), while the level was obviously lower in GDM normal weight group than that in NGT normal weight group(P<0.01).There were significant differences in blood insulin , blood sugar and HOMA -IR between GDM group and NGT group (P<0.05).In the pregnant women, omentin 1 was significantly negatively correlated with BMI , FBG, FINS, 1 h BG after OGTT and HOMA-IR (P<0.05).There was no obvious correlation between omentin 1 in pregnant women and cord blood and fetal birth weight .Conclusion Omentin concentration decreases in maternal serum of women with GDM , espe-cially in obese ones , and this may provide a novel approach to identify women with GDM and obese .