中国社区医师
中國社區醫師
중국사구의사
Chinese Community Doctors
2014年
30期
5-6
,共2页
去氢表雄酮%生理活性%微生物转化
去氫錶雄酮%生理活性%微生物轉化
거경표웅동%생리활성%미생물전화
Dehydroepiandrosterone%Physiological activity%Microbial transformation
为了解去氢表雄酮的生理活性及其微生物转化，为新型高效低毒的甾体化合物的研发奠定基础，本文综述了PUBMED 数据库1991-2013年去氢表雄酮的生理活性及其微生物转化的研究进展。得出结论：去氢表雄酮在抗肿瘤、保护中枢神经系统、调节等方面均有独特的生理活性；而且可利用微生物转化法制备出一系列新型、高效的甾体化合物，为新药的开发提供了良好的理论和应用基础。
為瞭解去氫錶雄酮的生理活性及其微生物轉化，為新型高效低毒的甾體化閤物的研髮奠定基礎，本文綜述瞭PUBMED 數據庫1991-2013年去氫錶雄酮的生理活性及其微生物轉化的研究進展。得齣結論：去氫錶雄酮在抗腫瘤、保護中樞神經繫統、調節等方麵均有獨特的生理活性；而且可利用微生物轉化法製備齣一繫列新型、高效的甾體化閤物，為新藥的開髮提供瞭良好的理論和應用基礎。
위료해거경표웅동적생리활성급기미생물전화，위신형고효저독적치체화합물적연발전정기출，본문종술료PUBMED 수거고1991-2013년거경표웅동적생리활성급기미생물전화적연구진전。득출결론：거경표웅동재항종류、보호중추신경계통、조절등방면균유독특적생리활성；이차가이용미생물전화법제비출일계렬신형、고효적치체화합물，위신약적개발제공료량호적이론화응용기출。
In this paper,to understand the physiological activity and microbial transformation of dehydroepiandrosterone,and to lay the foundation for the research and development of new type,high-efficiency and harmfulless steroidal compounds,the research progresses of physiological activity and microbial transformation of dehydroepiandrosterone from 1991 to 2013 in PUBMED database were summarized. Conclusion:Dehydroepiandrosterone had unique physiological activity on the antineoplastic, protection of the central nervous system,regulation and other aspectes.And we could product a series of new type and high-efficiency steroidal compounds by using microbial transformation process.It provided a good theoretical and applied foundation for the development of new drugs.
