CAJ | 학술논문

目的：探讨Claudin-3在不同转移淋巴结个数乳腺癌患者中表达的差异。方法将128例乳腺癌组织标本按淋巴结转移个数分组，转移淋巴结个数＜4个为A组，≥4个为B组，2组各64例。应用实时定量逆转录聚合酶链反应（ RT-PCR）检测2组乳腺癌组织Claudin-3的表达水平并进行比较。结果 A组Claudin-3 mRNA表达低于B组，2组比较有显著性差异（P＜0．05）。不同年龄、激素受体状态、CerbB-2、p53、ki67和组织学分级患者Claudin-3表达水平比较差异均无统计学意义（P均＞0．05）。结论 Claudin-3表达上调可促进乳腺癌的淋巴结转移，与预后不良有关。
목적：탐토Claudin-3재불동전이림파결개수유선암환자중표체적차이。방법장128례유선암조직표본안림파결전이개수분조，전이림파결개수＜4개위A조，≥4개위B조，2조각64례。응용실시정량역전록취합매련반응（ RT-PCR）검측2조유선암조직Claudin-3적표체수평병진행비교。결과 A조Claudin-3 mRNA표체저우B조，2조비교유현저성차이（P＜0．05）。불동년령、격소수체상태、CerbB-2、p53、ki67화조직학분급환자Claudin-3표체수평비교차이균무통계학의의（P균＞0．05）。결론 Claudin-3표체상조가촉진유선암적림파결전이，여예후불량유관。
Objective It is to investigate the difference of Claudin -3 expression between breast cancer patients had differ-ent number of metastatic lymph nodes .Methods 128 breast cancer tissue specimens were divided into two groups according to the number of metastatic lymph nodes , the number of metastatic lymph nodes <4 in Group A, and ≥4 in Group B, there were 64 cases in each group .The different expression of Claudin -3 in Group A and B were examined by RT -PCR and com-pared.Results The level of Claudin -3 was significantly lower in Group A than that in Group B , there was significant differ-ence (P<0.05).There were no significant differences in patiens with different age , status of hormone receptor, CerB-2, p53, ki67 and histologial type (all P>0.05).Conclusion Increasing expression of Claudin -3 is associated with the metas-tasis of breast cancer and lead to poor prognosis.