CAJ | 학술논문

目的：研究白介素-17（IL-17）与环氧化酶-2（COX-2）在口腔扁平苔藓、口腔鳞状细胞癌中的表达情况，分析两者的关系和临床意义。方法取20例口腔扁平苔藓及20例口腔鳞状细胞癌组织标本为研究对象，并选取20例正常口腔黏膜标本作为对照，采用免疫组化法检测IL-17、CXO-2的表达情况，分析IL-17、CXO-2的表达水平与口腔黏膜病变的关系。结果①对照组中6例（30％） IL-17呈阴性表达，14例（70％）呈不同程度的阳性表达；扁平苔藓组1例（5％） IL-17阴性表达，19例（95％）阳性表达；鳞癌组中均有阳性表达。经比较发现，IL-17在扁平苔藓组与鳞癌组阳性表达率均显著高于对照组（ P均＜0．05），但扁平苔藓组与鳞癌组IL-17阳性率比较无显著差异（P＞0．05）。②对照组中未见CXO-2阳性表达，扁平苔藓组10例（50％）阳性表达，鳞癌组16例（80％）阳性表达。经比较发现，CXO-2在扁平苔藓组与鳞癌组阳性表达率均显著高于对照组（P均＜0．05），且鳞癌组显著高于扁平苔藓组（P＜0．05）。结论 IL-17与CXO-2在口腔扁平苔藓以及鳞癌组织均高度表达，可能通过改变局部微环境而影响癌前病变及恶性肿瘤的进展。
목적：연구백개소-17（IL-17）여배양화매-2（COX-2）재구강편평태선、구강린상세포암중적표체정황，분석량자적관계화림상의의。방법취20례구강편평태선급20례구강린상세포암조직표본위연구대상，병선취20례정상구강점막표본작위대조，채용면역조화법검측IL-17、CXO-2적표체정황，분석IL-17、CXO-2적표체수평여구강점막병변적관계。결과①대조조중6례（30％） IL-17정음성표체，14례（70％）정불동정도적양성표체；편평태선조1례（5％） IL-17음성표체，19례（95％）양성표체；린암조중균유양성표체。경비교발현，IL-17재편평태선조여린암조양성표체솔균현저고우대조조（ P균＜0．05），단편평태선조여린암조IL-17양성솔비교무현저차이（P＞0．05）。②대조조중미견CXO-2양성표체，편평태선조10례（50％）양성표체，린암조16례（80％）양성표체。경비교발현，CXO-2재편평태선조여린암조양성표체솔균현저고우대조조（P균＜0．05），차린암조현저고우편평태선조（P＜0．05）。결론 IL-17여CXO-2재구강편평태선이급린암조직균고도표체，가능통과개변국부미배경이영향암전병변급악성종류적진전。
Objective It is to investigate the expression of COX -2 and IL-17 in the oral lichen planus and oral squa-mous cell carcinoma , and analyze their relationships and clinical significance .Methods The expression of Cox-2 and IL-17 of 20 cases of oral lichen planus ( lichen planus group ) , 20 cases of oral squamous cell carcinoma ( oscc group ) and 20 cases of normal oral mucosa ( control gorup ) were examined with immunohistochemical technique .The relationships of the expres-sion of Cox-2 and IL-17 with oral mucosal lesions were analyzed .Results①The IL-17 positive rate in control group , li-chen planus group and oscc group were 70%, 95% and 100% respectively .The IL-17 positive rate both in lichen planus group and oscc group were markedly higher than that in control group (all P<0.05).But there was no obvious difference of IL-17 positive rate between lichen planus group and oscc group .②The Cox-2 positive rate in control group , lichen planus group and oscc group were 0%, 50%and 80%respectively.The Cox-2 positive rate both in lichen planus group and oscc group were markedly higher than that in control group (all P<0.05), and COX-2 positive rate in oscc group were markedly higher than that in lichen planus group (P<0.05).C onclusion The expression of Cox -2 and IL-17 in the oral lichen pla-nus and mucosa squamous cell carcinoma are increased , they may be play an important role to influence the tumor microenvi-ronment in tumor development .