CAJ | 학술논문

目的：探讨中西医结合治疗对急性缺血性中风阴类证患者神经功能及高敏C反应蛋白（hs-CRP）、肿瘤坏死因子α（TNF-α）、白细胞介素-6（IL-6）浓度的影响。方法将100例缺血性中风阴类证住院患者随机分为治疗组和对照组各50例。2组患者均给予基础治疗及康复治疗，在此基础上治疗组给予益气活血、醒脑涤痰中药汤剂口服及丹红注射液静脉点滴，对照组给予低分子右旋糖苷、胞磷胆碱静脉点滴。2组患者分别于治疗前、治疗第14天采用美国国立卫生研究院卒中量表（ NIHSS）评价神经功能并测定hs-CRP、TNF-α、IL-6浓度。结果治疗后2组患者hs-CRP、TNF-α、IL-6浓度及NIHSS评分均较同组治疗前显著下降（P均＜0．05），且治疗组下降程度更明显（P均＜0．05）。结论中西医结合治疗方案能改善急性缺血性中风阴类证患者治疗前后神经功能，降低hs-CRP、TNF-α、IL-6浓度。
목적：탐토중서의결합치료대급성결혈성중풍음류증환자신경공능급고민C반응단백（hs-CRP）、종류배사인자α（TNF-α）、백세포개소-6（IL-6）농도적영향。방법장100례결혈성중풍음류증주원환자수궤분위치료조화대조조각50례。2조환자균급여기출치료급강복치료，재차기출상치료조급여익기활혈、성뇌조담중약탕제구복급단홍주사액정맥점적，대조조급여저분자우선당감、포린담감정맥점적。2조환자분별우치료전、치료제14천채용미국국립위생연구원졸중량표（ NIHSS）평개신경공능병측정hs-CRP、TNF-α、IL-6농도。결과치료후2조환자hs-CRP、TNF-α、IL-6농도급NIHSS평분균교동조치료전현저하강（P균＜0．05），차치료조하강정도경명현（P균＜0．05）。결론중서의결합치료방안능개선급성결혈성중풍음류증환자치료전후신경공능，강저hs-CRP、TNF-α、IL-6농도。
Objective It is to explore the influence of integrative medical therapy on neurological function and concentra -tions of hs-CRP, TNF-α, IL-6 in patients suffering from Yin syndrome type acute ischemic stroke .Methods One hun-dred patients suffering from Yin syndrome type acute ischemic stroke were randomly divided into the treatment group and con -trol group, each group had 50 cases.Both the groups were given basic treatment and rehabilitation .Meanwhile,the treatment group was given Chinese decoction with the effects of supplementing Qi and activating blood circulation , restoring conscious-ness and clearing phlegm by oral administration and Danhong injection by IV drip .The control group were given citicoline , low molecular weight dextran by IV drip .The scores of NIHSS were assessed , and the concentration of hs -CRP, TNF-α, IL-6 were determined after admission and 14 days'treatment.Results After treatment, the concentrations of hs -CRP, TNF-α, IL-6 and NIHSS scores were significantly lower than those before treatment in both groups (P<0.05).However, the concen-tration of those in treatment group were significantly lower than that in control group (P all<0.05).Conclusion The integra-tive medical therapy can significantly improve neurological functio ,decrease the concentration level of hs -CRP, TNF-α, IL-6 and NIHSS scores in patients suffering from Yin syndrome type acute ischemic stroke .