CAJ | 학술논문

MicroRNA(miRNA)是一类长约22 nt的非编码小RNA，广泛存在于各种生物中，调节生物体生长、发育和凋亡等过程。研究表明，miRNA 在猪肌肉、脂肪、生殖系统以及免疫系统等的发育过程中发挥着重要的调控作用。此外，高通量的新一代测序技术在猪miRNA的挖掘和差异表达研究中发挥着巨大的作用。文章综述了高通量的新一代测序技术在挖掘猪 miRNA 中的应用以及一些 miRNA 在猪脂肪代谢、肌肉发育、卵母细胞成熟和B、T淋巴细胞发育中的调控作用，旨在为猪miRNA的研究提供参考，为利用miRNA调控和改善猪肉品质、生长性能、繁殖性能以及免疫机能提供理论基础和研究思路。
MicroRNA(miRNA)시일류장약22 nt적비편마소RNA，엄범존재우각충생물중，조절생물체생장、발육화조망등과정。연구표명，miRNA 재저기육、지방、생식계통이급면역계통등적발육과정중발휘착중요적조공작용。차외，고통량적신일대측서기술재저miRNA적알굴화차이표체연구중발휘착거대적작용。문장종술료고통량적신일대측서기술재알굴저 miRNA 중적응용이급일사 miRNA 재저지방대사、기육발육、란모세포성숙화B、T림파세포발육중적조공작용，지재위저miRNA적연구제공삼고，위이용miRNA조공화개선저육품질、생장성능、번식성능이급면역궤능제공이론기출화연구사로。
MicroRNA (miRNA), a class of non-coding RNA (about 22 nt), widely exists in different organisms and plays an important role in growth, development, and apoptosis. Recently, many studies have shown that miRNAs serve as a regulatory mechanism in mediating the development of pig muscle, fat, reproductive and immunity traits. The next-generation of high-throughput sequencing technology plays a critical role on finding new miRNAs and identifying their different expressions in pig. In this review, we summarize the application of the next-generation of high-throughput sequencing technology in the study of pig miRNAs as well as the regulatory roles of several impor-tant miRNAs in fat metabolism, muscle development, oocyte maturation and development of B cells and T cells. This review will provide insight into the research on pig miRNAs, and some ideas on how to improve pork quality, growth, reproductive and immunity performance.