CAJ | 학술논문

目的：对 Fascin 和 Ezrin 在膀胱尿路上皮癌的表达及二者的表达的相关性进行研究。方法采用免疫组化 S －P 法检测 Fascin 和 Ezrin 在10例膀胱癌旁黏膜及109例膀胱尿路上皮癌中的表达情况，探讨二者与膀胱尿路上皮癌的组织学分级及临床分期等临床病理特征的关系，统计分析二者在膀胱尿路上皮癌的表达的相关性。结果 Fascin 在10例癌旁黏膜组织中均不表达，Ezrin 在10例癌旁黏膜组织的表达阳性率为10％，二者在109例膀胱尿路上皮癌中的表达阳性率分别为84％，77％。二者的表达均与膀胱尿路上皮癌的组织学分级、临床分期及淋巴结转移有关（P 均＜0．05），与患者的性别及肿瘤是否多发无关（P 均＞0．05）。二者在膀胱尿路上皮癌的表达具有相关性，为正相关（r ＝0．9124，P ＜0．05）。结论推测在膀胱尿路上皮癌中 Fascin 与 Ezrin 具有协同作用，联合检测 Fascin 和 Ezrin 有助于判断膀胱尿路上皮癌的侵袭转移及预后。
목적：대 Fascin 화 Ezrin 재방광뇨로상피암적표체급이자적표체적상관성진행연구。방법채용면역조화 S －P 법검측 Fascin 화 Ezrin 재10례방광암방점막급109례방광뇨로상피암중적표체정황，탐토이자여방광뇨로상피암적조직학분급급림상분기등림상병리특정적관계，통계분석이자재방광뇨로상피암적표체적상관성。결과 Fascin 재10례암방점막조직중균불표체，Ezrin 재10례암방점막조직적표체양성솔위10％，이자재109례방광뇨로상피암중적표체양성솔분별위84％，77％。이자적표체균여방광뇨로상피암적조직학분급、림상분기급림파결전이유관（P 균＜0．05），여환자적성별급종류시부다발무관（P 균＞0．05）。이자재방광뇨로상피암적표체구유상관성，위정상관（r ＝0．9124，P ＜0．05）。결론추측재방광뇨로상피암중 Fascin 여 Ezrin 구유협동작용，연합검측 Fascin 화 Ezrin 유조우판단방광뇨로상피암적침습전이급예후。
Objective It is to study the expressions of Fascin and Ezrin in bladder urothelial carcinoma and the correla-tions between them.Methods The expression of Fascin and Ezrin in 10 cases of mucous membrane beside bladder cancer and 109 cases of bladder urothelial carcinoma was detected by immunohistochemical S -P method, to explore their relationship with clinical pathological characteristics such as histological grading and clinical staging of bladder urothelial carcinoma, and statistical analysis about the correlation of the expression in bladder urothelial carcinoma was performed.Results Fascin was not expressed in 10 case of mucosa tissue adjacent to carcinoma, positive rate about the expression of Ezrin in 10 cases of mu-cosa tissue adjacent to carcinoma was 10%, the expression positive rates about Fascin and Ezrin in 109 cases of bladder urothelial carcinoma were respectively 84%, 77%.The expressions of the two were related with histological grading, clinical stage and lymph node metastasis of bladder urothelial carcinoma (P <0.05), but had nothing to do with patients’ gender and whether the tumor was multiple or not (P >0.05).Both Fascin and Ezrin had some correlation expressed in bladder urothelial carcinoma, and the correlation was positive(r =0.912 4,P <0.05).Conclusion Fascin and Ezrin in bladder urothelial carci-noma have synergy, detection both Fascin and Ezrin is helpful for the diagnosis of invasion, metastasis and prognosis of blad-der urothelial carcinoma.