中外医疗
中外醫療
중외의료
CHINA FOREIGN MEDICAL TREATMENT
2014年
25期
50-51,53
,共3页
慢性乙肝%复方甘草酸苷注射液%阿德福韦酯
慢性乙肝%複方甘草痠苷註射液%阿德福韋酯
만성을간%복방감초산감주사액%아덕복위지
Chronic hepatitis B%Compound Glycyrrhizin Injection%Adefovir Dipivoxil
目的：探究复方甘草酸苷辅助治疗慢性乙型肝炎患者的临床疗效。方法将该院2009年1月—2013年1月之间的60例慢性乙肝患者进行随机分组，对照组30例患者采用阿德福韦酯治疗，观察组30例患者则在对照组治疗基础上加用复方甘草酸苷治疗，两组患者的治疗时间均为1年，分别在患者治疗24、48周时进行ALT复常率、HBV-DNA以及HBeAg的转阴率的统计对比。结果两组患者治疗24周后ALT正常率均为100%，而48周时对照组患者降为70%；观察组患者治疗24、48周时HBV-DNA转阴率分别为73.3%和86.7%，显著高于对照组的46.7%和60.0%；观察组患者治疗24、48周时HBeAg转阴率分别为33.3%和56.7%，显著高于对照组的13.3%和20.0%。结论复方甘草酸苷联合阿德福韦酯治疗慢性乙肝有着显著的疗效，能够迅速抑制病毒复制，起效更快，值得在临床上推广和应用。
目的：探究複方甘草痠苷輔助治療慢性乙型肝炎患者的臨床療效。方法將該院2009年1月—2013年1月之間的60例慢性乙肝患者進行隨機分組，對照組30例患者採用阿德福韋酯治療，觀察組30例患者則在對照組治療基礎上加用複方甘草痠苷治療，兩組患者的治療時間均為1年，分彆在患者治療24、48週時進行ALT複常率、HBV-DNA以及HBeAg的轉陰率的統計對比。結果兩組患者治療24週後ALT正常率均為100%，而48週時對照組患者降為70%；觀察組患者治療24、48週時HBV-DNA轉陰率分彆為73.3%和86.7%，顯著高于對照組的46.7%和60.0%；觀察組患者治療24、48週時HBeAg轉陰率分彆為33.3%和56.7%，顯著高于對照組的13.3%和20.0%。結論複方甘草痠苷聯閤阿德福韋酯治療慢性乙肝有著顯著的療效，能夠迅速抑製病毒複製，起效更快，值得在臨床上推廣和應用。
목적：탐구복방감초산감보조치료만성을형간염환자적림상료효。방법장해원2009년1월—2013년1월지간적60례만성을간환자진행수궤분조，대조조30례환자채용아덕복위지치료，관찰조30례환자칙재대조조치료기출상가용복방감초산감치료，량조환자적치료시간균위1년，분별재환자치료24、48주시진행ALT복상솔、HBV-DNA이급HBeAg적전음솔적통계대비。결과량조환자치료24주후ALT정상솔균위100%，이48주시대조조환자강위70%；관찰조환자치료24、48주시HBV-DNA전음솔분별위73.3%화86.7%，현저고우대조조적46.7%화60.0%；관찰조환자치료24、48주시HBeAg전음솔분별위33.3%화56.7%，현저고우대조조적13.3%화20.0%。결론복방감초산감연합아덕복위지치료만성을간유착현저적료효，능구신속억제병독복제，기효경쾌，치득재림상상추엄화응용。
Objective To explore the clinical efficacy of Compound Glycyrrhizin Injection as the adjuvant therapy for patients with chronic hepatitis B. Methods 60 cases of chronic hepatitis B patients admitted in our hospital from January 2009 to January 2013 were randomly divided into two groups. 30 cases in the control group were treated with Adefovir Dipivoxil, and 30 cases in the ob-servation group were treated with Compound Glycyrrhizin Injection on the basis of the treatment given to the control group. The course of treatment of both groups was 1 year. The recovery rate of ALT, HBV-DNA and HBeAg negative rate at 24, 48 weeks of treatment were counted and compared, respectively. Results The rate of normal ALT of both groups of patients after 24 weeks of treatment was 100%, however, that of the control group decreased to 70% at 48 weeks of treatment; the HBV-DNA turning nega-tive rate of the observation group at 24, 48 weeks of treatment was 73.3%, 86.7%, respectively, significantly higher than 46.7%, 60.0% of the control group, respectively; the HBeAg turning negative rate of the observation group at 24, 48 weeks of treatment was 33.3%, 56.7%, respectively, significantly higher than the control group's 13.3%, 20.0%, respectively. Conclusion Compound Glycyrrhizin Injection combined with Adefovir Dipivoxil in the treatment of chronic hepatitis B has a significant effect, which can rapidly inhibit the virus replication with faster onset, and is worthy of clinical popularization and application.
