中外医疗
中外醫療
중외의료
CHINA FOREIGN MEDICAL TREATMENT
2014年
33期
6-7
,共2页
丹参多酚酸盐%急性冠脉综合征%超敏C反应蛋白%肿瘤坏死因子-α
丹參多酚痠鹽%急性冠脈綜閤徵%超敏C反應蛋白%腫瘤壞死因子-α
단삼다분산염%급성관맥종합정%초민C반응단백%종류배사인자-α
Salvianolate%Acute coronary syndrome%Hypersensitive C reaction protein%Tumor necrosis factor-α
目的：探讨丹参多酚酸盐治疗急性冠脉综合征（ACS）的临床疗效，以及对患者血清超敏C反应蛋白（hs-CRP）及肿瘤坏死因子-α（TNF-α）水平的影响。方法选择符合标准的患者80例，随机分为观察组40例和对照组40例，所有患者均给予常规治疗，观察组加用丹参多酚酸盐，观察比较两组患者治疗前临床症状、血清hs-CRP及TNF-α变化。结果入院时两组患者血清hs-CRP及TNF-α水平相似，差异无统计学意义（P＞0.05）；治疗7 d、14 d，两组患者血清hs-CRP及TNF-α水平较入院时均下降，差异有统计学意义（P＜0.05），但是观察组较对照组下降更显著（P＜0.05）。观察组患者显效30例、有效9例和无效1例，对照组患者显效20例、有效10例和无效10例，差异有统计学意义（P＜0.05）。结论丹参多酚酸盐可有效降低ACS患者血清hs-CRP及TNF-α水平，减轻炎症反应程度，改善患者临床症状，值得临床推广应用。
目的：探討丹參多酚痠鹽治療急性冠脈綜閤徵（ACS）的臨床療效，以及對患者血清超敏C反應蛋白（hs-CRP）及腫瘤壞死因子-α（TNF-α）水平的影響。方法選擇符閤標準的患者80例，隨機分為觀察組40例和對照組40例，所有患者均給予常規治療，觀察組加用丹參多酚痠鹽，觀察比較兩組患者治療前臨床癥狀、血清hs-CRP及TNF-α變化。結果入院時兩組患者血清hs-CRP及TNF-α水平相似，差異無統計學意義（P＞0.05）；治療7 d、14 d，兩組患者血清hs-CRP及TNF-α水平較入院時均下降，差異有統計學意義（P＜0.05），但是觀察組較對照組下降更顯著（P＜0.05）。觀察組患者顯效30例、有效9例和無效1例，對照組患者顯效20例、有效10例和無效10例，差異有統計學意義（P＜0.05）。結論丹參多酚痠鹽可有效降低ACS患者血清hs-CRP及TNF-α水平，減輕炎癥反應程度，改善患者臨床癥狀，值得臨床推廣應用。
목적：탐토단삼다분산염치료급성관맥종합정（ACS）적림상료효，이급대환자혈청초민C반응단백（hs-CRP）급종류배사인자-α（TNF-α）수평적영향。방법선택부합표준적환자80례，수궤분위관찰조40례화대조조40례，소유환자균급여상규치료，관찰조가용단삼다분산염，관찰비교량조환자치료전림상증상、혈청hs-CRP급TNF-α변화。결과입원시량조환자혈청hs-CRP급TNF-α수평상사，차이무통계학의의（P＞0.05）；치료7 d、14 d，량조환자혈청hs-CRP급TNF-α수평교입원시균하강，차이유통계학의의（P＜0.05），단시관찰조교대조조하강경현저（P＜0.05）。관찰조환자현효30례、유효9례화무효1례，대조조환자현효20례、유효10례화무효10례，차이유통계학의의（P＜0.05）。결론단삼다분산염가유효강저ACS환자혈청hs-CRP급TNF-α수평，감경염증반응정도，개선환자림상증상，치득림상추엄응용。
Objective To investigate the clinical efficacies of salvianolate in the treatment of acute coronary syndrome (ACS) and the effects of it on the serum levels of hypersensitive C reaction protein (hs-CRP) and tumor necrosis factor-α(TNF-α) in the pa-tients. Methods 80 eligible patients were selected and randomly divided into observation group and control group, with 40 patients in each group. All the patients were given the conventional therapies, but the patients of the observation group were given sal-vianolate additionally. And the changes in clinical symptoms and serum TNF-α and hs-CRP levels were observed and compared. Results On admission, the patients of the two groups had similar serum TNF-α and hs-CRP levels, and the differences were not statistically insignificant (P>0.05). At 7d and 14d after the therapies, the serum TNF-αand hs-CRP levels in the patients of both groups were decreased when compared with those on admission, and the differences were statistically significant (P<0.05), but they were decreased more significantly in the patients of the observation group (P<0.05). Of the observation group, 30 patients were re-sponsive to the therapies excellently, 9 patients were responsive effectively, and 1 patient was unresponsive; while of the control group, 20 patients were responsive to the therapies excellently, 10 patients were responsive effectively, and 10 patients were unre-sponsive;and the difference was statistically significant(P<0.05). Conclusion Salvianolate can effectively decrease the serum TNF-α and hs-CRP levels, lighten the degree of inflammatory reaction, and improve the clinical symptoms in ACS patients, and conse-quently is worthy of clinical application.
