CAJ | 학술논문

目的：观察甲钴胺注射液联合组合型人工肾对尿毒症皮肤瘙痒的疗效。方法2009年1月至2012年1月选择该院行维持性血液透析并出现严重皮肤瘙痒的尿毒症患者38例，随机分为对照组和治疗组，各19例。对照组予常规血液透析治疗，口服抗组胺药、镇静及外用止痒药等一般治疗。治疗组在对照组基础上加用血液灌流（即组合型人工肾）及甲钴胺治疗，观察两组患者治疗前及治疗8周后血钙、磷、全段甲状旁腺激素（iPTH）、β2_微球蛋白（β2_MG）及皮肤瘙痒评分变化情况。结果治疗组治疗后与治疗前及对照组治疗后比较，血磷、iPTH、β2_MG、皮肤瘙痒评分均下降，差异均有统计学意义（P<0.05）。结论甲钴胺注射液联合组合型人工肾可减轻尿毒症皮肤瘙痒症状，降低血磷、iPTH和β2_MG。
목적：관찰갑고알주사액연합조합형인공신대뇨독증피부소양적료효。방법2009년1월지2012년1월선택해원행유지성혈액투석병출현엄중피부소양적뇨독증환자38례，수궤분위대조조화치료조，각19례。대조조여상규혈액투석치료，구복항조알약、진정급외용지양약등일반치료。치료조재대조조기출상가용혈액관류（즉조합형인공신）급갑고알치료，관찰량조환자치료전급치료8주후혈개、린、전단갑상방선격소（iPTH）、β2_미구단백（β2_MG）급피부소양평분변화정황。결과치료조치료후여치료전급대조조치료후비교，혈린、iPTH、β2_MG、피부소양평분균하강，차이균유통계학의의（P<0.05）。결론갑고알주사액연합조합형인공신가감경뇨독증피부소양증상，강저혈린、iPTH화β2_MG。
Objective To observe the effect of mecobalamin injection combined with assembled artificial kidney in uremic pruritus. Methods A total of 38 patients with uremia keeping hemodialysis from January 2009 to January 2012 were randomly divid_ed into the treatment group and the control group,19 cases in each group. The control group was received routine hemodialysis treat_ment,as well as oral antihistamines,sedation antipruritic drugs topical. The treatment group was treated with hemoperfusion (assem_bled artificial kidney) and mecobalamin. The two groups were observed before and 8 weeks after treatment on serum calcium ,phos phorus and intact parathyroid hormone iPTH;β2_microglobulin(β2_MG) and pruritus score changes. Results Compared with the treatment group before the treatment the control group after treatment,serum phosphorus,iPTH,β2_MG,pruritus score decreased,the difference was statistically significant(P<0.05). Conclusion Mecobalamin injection joint combined type artificial kidney may relieve uremic pruritus symptom,reduce serum phosphorus,iPTH andβ2_MG.