CAJ | 학술논문

目的：比较阿立哌唑与利培酮治疗精神分裂症的临床疗效和安全性。方法：2011年12月-2013年6月收治精神分裂症患者80例，随机分为研究组和对照组，各40例。以阳性和阴性症状量表(PANSS)评定疗效，以治疗中需处理的不良反应量表(TESS)评定不良反应。结果：治疗后第2周、4周、8周两组PANSS部分及各因子分与治疗前比较均显著下降。治疗第8周，两组有效率差异无统计学意义(P＞0.05)。两组不良反应轻微，研究组锥体外系反应、停经及体重增加发生率显著低于对照组。结论：阿立哌唑抗精神病作用与利培酮相当，而且阿立哌唑安全性更高，依从性更好。
목적：비교아립고서여리배동치료정신분렬증적림상료효화안전성。방법：2011년12월-2013년6월수치정신분렬증환자80례，수궤분위연구조화대조조，각40례。이양성화음성증상량표(PANSS)평정료효，이치료중수처리적불량반응량표(TESS)평정불량반응。결과：치료후제2주、4주、8주량조PANSS부분급각인자분여치료전비교균현저하강。치료제8주，량조유효솔차이무통계학의의(P＞0.05)。량조불량반응경미，연구조추체외계반응、정경급체중증가발생솔현저저우대조조。결론：아립고서항정신병작용여리배동상당，이차아립고서안전성경고，의종성경호。
Objective:To compare the clinical efficacy and safety of aripiprazole and risperidone in the treatment of schizophrenia. Methods:80 patients with schizophrenic were selected from December 2011 to June 2013.They were randomly divided into the study group and the control group with 40 cases in each.The treatment effect assessed by positive and negative symptom scale(PANSS),assessment of adverse reaction using Treatment Emergent SymptomScale(TESS).Results:In the second,fourth,eighth weeks after the treatment,PANSS part and the factor scores in two group were significantly decreased than before the treatment.At eighth weeks,the efficiency had no significant difference between two groups(P>0.05).The adverse reactions in two groups both were mild,the extrapyramidal reactions and the rate of menopause and weight gain in the study group were significantly lower than in the control group.Conclusion:Aripiprazole and risperidone are equivalent in anti psychotic,but aripiprazole has higher safety and better compliance.