CAJ | 학술논문

目的：分析血清铁蛋白（ SF）水平与肝病类型及肝脏炎症程度的关系。方法选取203例入院时SF升高的急慢性肝病患者，采用全自动生化分析仪检测患者清晨空腹血清丙氨酸氨基转移酶（ ALT）、天门冬氨酸氨基转移酶（AST）、白蛋白（ALB），同时采用免疫比浊法检测SF、络合法测定血清铁（SI），分析SF、SI与肝功能炎症指标相关性，及SF、SI在不同类型肝病、不同程度肝脏炎症患者中的变化特点。结果 SF、SI与ALT、AST均呈正相关（P均＜0．01），SF与ALB呈负相关（P＜0．01）。 SF水平在戊型肝炎、药物性肝炎、乙型肝炎、丙型肝炎患者中依次升高（χ2＝13．551，P＜0．01），ALT、AST的升高程度同SF一致；SI在不同类型肝病患者之间的差异无统计学意义（ P＞0．05）。 SF在急性肝炎与肝衰竭中的升高水平较慢性肝炎、肝硬化、肝癌患者明显；SI在肝癌患者表达量最低，其余四组之间的差异无统计学意义（P＞0．05）。结论 SF与肝脏炎症程度正相关，在丙肝及肝衰竭患者中，SF比ALT、AST更能反映患者的病情。
목적：분석혈청철단백（ SF）수평여간병류형급간장염증정도적관계。방법선취203례입원시SF승고적급만성간병환자，채용전자동생화분석의검측환자청신공복혈청병안산안기전이매（ ALT）、천문동안산안기전이매（AST）、백단백（ALB），동시채용면역비탁법검측SF、락합법측정혈청철（SI），분석SF、SI여간공능염증지표상관성，급SF、SI재불동류형간병、불동정도간장염증환자중적변화특점。결과 SF、SI여ALT、AST균정정상관（P균＜0．01），SF여ALB정부상관（P＜0．01）。 SF수평재무형간염、약물성간염、을형간염、병형간염환자중의차승고（χ2＝13．551，P＜0．01），ALT、AST적승고정도동SF일치；SI재불동류형간병환자지간적차이무통계학의의（ P＞0．05）。 SF재급성간염여간쇠갈중적승고수평교만성간염、간경화、간암환자명현；SI재간암환자표체량최저，기여사조지간적차이무통계학의의（P＞0．05）。결론 SF여간장염증정도정상관，재병간급간쇠갈환자중，SF비ALT、AST경능반영환자적병정。
Objective To analyze the relationships of serum ferritin ( SF) level, degree of Liver inflammation and types in patients with liver disease.Methods Alanine aminotransferase (ALT), aspartate aminotransferase (AST) and albumin ( ALB) ( by automatic biochemical analyzer ) and SF ( by immune turbidimetry ) , serum iron ( SI ) ( by complex legal) were detected and analyzed in 203 hospital patients of acute or chronic liver injury , whose SF were higher than nor-mal.The correlations between SF , SI and indicators of liver inflammation were analyzed as wel as the changes of SF and SI in patients with different liver cancer types and pathological degrees .Results Positively correlation was detected between the SF, SI and the ALT, AST (all P<0.01).SF was negatively correlated with ALB (P<0.01).The degree of elevated SF was the order of HEV infection , drug-induced hepatitis, HBV infection and HCV infection (χ2 =13.551, P<0.01) in different etiology , and meanwhile , ALT and AST followed the same order .The SI levels showed no statistical significance in different etiology(P>0.05).The levels of serum ferritin in acute hepatitis and liver failure patients were significantly higher than those in chronic hepatitis , liver cirrhosis and hepatocellular carcinoma .SI level was the lowest in hepatocellular carcinoma, and the difference in the remaining four groups performed no statistical significance (P>0.05).Conclusions SF is positively correlated with indicators of liver inflammation ( ALT, AST) .In patients with hepatitis C and liver fail-ure, SF can evaluate liver function more objectively and accurately than ALT and AST in clinical .