CAJ | 학술논문

目的：探讨神经元特异性烯醇化酶（NSE）在热性惊厥（FS）患儿的变化及其临床意义。方法根据惊厥发作次数、惊厥持续时间等将研究对象分为FS组（单纯FS、发作1次、抽搐时间小于15 min）、FS1组（复杂FS、发作2次、每次抽搐时间小于15 min）、FS2组（复杂FS、发作1次、抽搐时间大于15 min）和对照组，各50例。采用放射免疫分析法检测各组患儿血清NSE水平。结果 FS组患儿发作第1天及第7天血清NSE水平[分别为（15.16±1.68）、（14.96±1.65）ng/mL]与对照组[分别为（15.00±1.88）、（14.82±1.46）ng/mL]比较，差异均无统计学意义（P＞0.05）；FS1、FS2组患儿发作第1天血清NSE水平[分别为（19.90±3.63）、（27.44±9.34）ng/mL]明显高于对照组，差异均有统计学意义（P<0.05）；FS2组患儿发作第1天血清NSE水平[（27.44±9.34）ng/mL]较FS1组[（19.90±3.63）ng/mL]高，差异有统计学意义（P<0.05）；FS2组患儿发作第7天血清NSE水平[（16.61±3.32）ng/ml]仍高于对照组，差异有统计学意义（P<0.05）。结论单纯FS发作后血清NSE水平正常，但不能完全排除脑神经元损伤，复杂FS发作后有明显脑神经元损伤，长程发作较反复短时间发作神经元损伤更重。
목적：탐토신경원특이성희순화매（NSE）재열성량궐（FS）환인적변화급기림상의의。방법근거량궐발작차수、량궐지속시간등장연구대상분위FS조（단순FS、발작1차、추휵시간소우15 min）、FS1조（복잡FS、발작2차、매차추휵시간소우15 min）、FS2조（복잡FS、발작1차、추휵시간대우15 min）화대조조，각50례。채용방사면역분석법검측각조환인혈청NSE수평。결과 FS조환인발작제1천급제7천혈청NSE수평[분별위（15.16±1.68）、（14.96±1.65）ng/mL]여대조조[분별위（15.00±1.88）、（14.82±1.46）ng/mL]비교，차이균무통계학의의（P＞0.05）；FS1、FS2조환인발작제1천혈청NSE수평[분별위（19.90±3.63）、（27.44±9.34）ng/mL]명현고우대조조，차이균유통계학의의（P<0.05）；FS2조환인발작제1천혈청NSE수평[（27.44±9.34）ng/mL]교FS1조[（19.90±3.63）ng/mL]고，차이유통계학의의（P<0.05）；FS2조환인발작제7천혈청NSE수평[（16.61±3.32）ng/ml]잉고우대조조，차이유통계학의의（P<0.05）。결론단순FS발작후혈청NSE수평정상，단불능완전배제뇌신경원손상，복잡FS발작후유명현뇌신경원손상，장정발작교반복단시간발작신경원손상경중。
Objective To investigate the change and its significance of serum neuron specific enolase (NSE)in children with febrile seizure(FS). Methods According to the frequency and duration of FS,the research object was divided into four groups,i.e. group FS(simple FS,1 seizure lasting less than 15 min),group FS1(complex FS,2 seizure lasting less than 15 min), group FS2 (complex FS,1 seizure lasting more than 15 min) and the control group,50 cases in each group. It was adopted radio-im-muni-assay to detect the serum NSE concentration. Results The difference had no statistical significance in the concentration of serum NSE on the 1st and 7th days of FS between simple group FS and the control group[(15.16±1.68),(14.96±1.65)ng/mL respectively]vs.[(15.00±1.88)ng/mL,(14.82±1.46)ng/mL respectively](P>0.05),the concentrations of serum NSE in the group FS1,group FS2 on the 1st day was higher than those of the control group[(19.90±3.63)ng/mL vs. (27.44±9.34)ng/mL respectively]. There was statistical significance in difference(P<0.05). The concentrations of serum NSE in the group FS1,group FS2, whose FS duration was over 15 min was higher than those whose FS was repeated and short(>twice,<15 min)[(27.44±9.34 )ng/mL vs.(19.90± 3.63)ng/mL], whose difference had statistical significance(P<0.05). The concentrations of serum NSE[(16.61±3.32)ng/mL] of the FS patients lasted over 15 min on the 7th day was higher than that of the control group ,whose difference had statistical signifi-cance(P<0.05). Conclusion The serum NSE concentration after simple FS is normal. The neurons damage should be considered. The complex FS may lead to obvious neurons damage. The degree of long-time attack is heavier to neuron damage than that of re-peated short-time occurrence.