中外医疗
中外醫療
중외의료
CHINA FOREIGN MEDICAL TREATMENT
2014年
32期
26-27,29
,共3页
肿瘤标志物%生化指标%联合检测%良恶性胸腹腔积液%诊断作用
腫瘤標誌物%生化指標%聯閤檢測%良噁性胸腹腔積液%診斷作用
종류표지물%생화지표%연합검측%량악성흉복강적액%진단작용
Tumor markers%Biochemical index%Combined detection%Benign and malignant pleural and peritoneal effusion%Ef_fect of diagnosis
目的：探讨良恶性胸腔积液生化指标及肿瘤标志物联检作用。方法选取胸腹腔积液患者100例,采用生化指标及肿瘤标志物联合检测,其中良性组60例,恶性组40例。采用罗氏Cobas e411全自动电化学发光分析仪及配套设施实施检测操作,入院治疗前,对患者空腹静脉血和胸腹腔积液进行抽取,离心后,将血清和上清液取出完成相关测定。结果相较良性组病例,恶性组CYFRA21-1﹑CEA﹑CA724﹑CA125浓度均居较高水平,分别为﹙124.8±26.4﹚ng/mL,﹙166.9±54.3﹚ng/mL,﹙39.5±14.8﹚U/mL,﹙1205.7±174.2﹚U/mL。差异有统计学意义﹙P<0.05﹚。 CYFRA21-1﹑CEA﹑CA724﹑CA125联检相较单项有更高特异度和敏感度﹙P<0.05﹚。结论胸腹腔积液性质鉴别诊断中,对血清与胸腹腔积液中的CYFRA21-1﹑CEA﹑CA724﹑CA125检测,有较高临床价值,特别是4种指标联合,敏感度和特异度居更高水平,LDH﹑GLU﹑FT生化指标可辅助诊断,值得临床引起重视,并广泛推广应用。
目的：探討良噁性胸腔積液生化指標及腫瘤標誌物聯檢作用。方法選取胸腹腔積液患者100例,採用生化指標及腫瘤標誌物聯閤檢測,其中良性組60例,噁性組40例。採用囉氏Cobas e411全自動電化學髮光分析儀及配套設施實施檢測操作,入院治療前,對患者空腹靜脈血和胸腹腔積液進行抽取,離心後,將血清和上清液取齣完成相關測定。結果相較良性組病例,噁性組CYFRA21-1﹑CEA﹑CA724﹑CA125濃度均居較高水平,分彆為﹙124.8±26.4﹚ng/mL,﹙166.9±54.3﹚ng/mL,﹙39.5±14.8﹚U/mL,﹙1205.7±174.2﹚U/mL。差異有統計學意義﹙P<0.05﹚。 CYFRA21-1﹑CEA﹑CA724﹑CA125聯檢相較單項有更高特異度和敏感度﹙P<0.05﹚。結論胸腹腔積液性質鑒彆診斷中,對血清與胸腹腔積液中的CYFRA21-1﹑CEA﹑CA724﹑CA125檢測,有較高臨床價值,特彆是4種指標聯閤,敏感度和特異度居更高水平,LDH﹑GLU﹑FT生化指標可輔助診斷,值得臨床引起重視,併廣汎推廣應用。
목적：탐토량악성흉강적액생화지표급종류표지물련검작용。방법선취흉복강적액환자100례,채용생화지표급종류표지물연합검측,기중량성조60례,악성조40례。채용라씨Cobas e411전자동전화학발광분석의급배투설시실시검측조작,입원치료전,대환자공복정맥혈화흉복강적액진행추취,리심후,장혈청화상청액취출완성상관측정。결과상교량성조병례,악성조CYFRA21-1﹑CEA﹑CA724﹑CA125농도균거교고수평,분별위﹙124.8±26.4﹚ng/mL,﹙166.9±54.3﹚ng/mL,﹙39.5±14.8﹚U/mL,﹙1205.7±174.2﹚U/mL。차이유통계학의의﹙P<0.05﹚。 CYFRA21-1﹑CEA﹑CA724﹑CA125련검상교단항유경고특이도화민감도﹙P<0.05﹚。결론흉복강적액성질감별진단중,대혈청여흉복강적액중적CYFRA21-1﹑CEA﹑CA724﹑CA125검측,유교고림상개치,특별시4충지표연합,민감도화특이도거경고수평,LDH﹑GLU﹑FT생화지표가보조진단,치득림상인기중시,병엄범추엄응용。
Objective To investigate the value of combined detection of benign and malignant pleural effusion biochemical index and tumor markers. Methods 100 patients with pleural and peritoneal effusion were selected. Combined detection of biochemical indexes and tumor markers were used. There were 60 patients in the benign group, and 40 cases in the malignant group. Roche Cobas e411 automatic electrochemiluminescence analyzer and supporting facilities were used to implement the inspection opera_tion. Before the hospitalized treatment, the fasting venous blood and the pleural and peritoneal effusion of the patients were ex_tracted, and after centrifugating, the serum and liquid supernatant were taken out and the related detection was completed. Results The level of CYFRA21-1, CEA, CA724, CA125 of the malignant group was (124.8±26.4) ng/mL, (166.9±54.3) ng/mL, (39.5±14.8) U/mL,(1205.7±174.2) U/mL, respectively, higher than that of the benign group, respectively with statistical differences (P<0.05). And the combined detection of CYFRA21-1, CEA, CA724, CA125 had higher specificity and sensitivity than single detection (P<0.05). Conclusion In the differential diagnosis of benign and malignant pleural and peritoneal effusion, the detection of CYFRA21-1, CEA, CA724, CA125 in serum and pleural and peritoneal effusion has high clinical value, especially the combined detection of the four indexes has higher sensitivity and specificity, and LDH, GLU, FT biochemical indicators can be used as the auxiliary diagnosis, these are worthy of clinical attention and wide application and promotion.
