CAJ | 학술논문

目的：探讨男性肥胖患者中血尿酸(SUA)与体脂分布及代谢综合征(MS)的相关性。方法选取2012-2014年门诊就诊的133例肥胖患者,体重指数(BMI)均>25.0 kg/m2,均未经降血糖﹑降血脂﹑利尿﹑降压﹑抗尿酸药物治疗。测定血清胰岛素及生化指标,用CT在脐水平测定腹部脂肪分布。结果直线相关分析显示SUA与BMI﹑腰围﹑内脏脂肪﹑内脏脂肪/皮下脂肪比值﹑空腹血糖﹑HOMA-IR﹑甘油三酯﹑血肌酐﹑收缩压﹑舒张压呈正相关,相关系数分别为0.361﹑0.446﹑0.634﹑0.360﹑0.193﹑0.287﹑0.477﹑0.259﹑0.280﹑0.181；多元逐步回归分析显示对SUA影响最大的因素依次为内脏脂肪面积﹑甘油三酯,标准化回归系数分别为0.533﹑0.183；内脏脂肪蓄积随血尿酸水平升高明显增加,更高的4分位数血尿酸对应更高的内脏脂肪面积(P<0.05)。 MS组SUA水平高于非MS组者[(434.6±69.6)umol/L vs (367.0±104.9)umol/L,P<0.01]；Spearman秩相关分析显示SUA水平随MS组分数增加而增高(P<0.01)。结论SUA水平与内脏脂肪蓄积相关；代谢综合征患者SUA水平更高。
목적：탐토남성비반환자중혈뇨산(SUA)여체지분포급대사종합정(MS)적상관성。방법선취2012-2014년문진취진적133례비반환자,체중지수(BMI)균>25.0 kg/m2,균미경강혈당﹑강혈지﹑이뇨﹑강압﹑항뇨산약물치료。측정혈청이도소급생화지표,용CT재제수평측정복부지방분포。결과직선상관분석현시SUA여BMI﹑요위﹑내장지방﹑내장지방/피하지방비치﹑공복혈당﹑HOMA-IR﹑감유삼지﹑혈기항﹑수축압﹑서장압정정상관,상관계수분별위0.361﹑0.446﹑0.634﹑0.360﹑0.193﹑0.287﹑0.477﹑0.259﹑0.280﹑0.181；다원축보회귀분석현시대SUA영향최대적인소의차위내장지방면적﹑감유삼지,표준화회귀계수분별위0.533﹑0.183；내장지방축적수혈뇨산수평승고명현증가,경고적4분위수혈뇨산대응경고적내장지방면적(P<0.05)。 MS조SUA수평고우비MS조자[(434.6±69.6)umol/L vs (367.0±104.9)umol/L,P<0.01]；Spearman질상관분석현시SUA수평수MS조분수증가이증고(P<0.01)。결론SUA수평여내장지방축적상관；대사종합정환자SUA수평경고。
Objective We investigated the relationship between serum uric acid (SUA) and body fat distribution, metabolic syn-drome(MS) in obese men. Methods 133 cases of obese outpatients from year 2012 to 2014, with body mass index(BMI)≥25.0 Kg/m2, were enrolled in the study. These patients have never been given hypoglycemic, hypolipidemic, hydragogue, anti-hypertensive or anti-hyperuricemic agents. Body fat distribution was measured by computed tomography (CT) scanning at the umbilical level. Serum insulin and other biochemical parameters were also measured. Results Linear correlation analysis showed that SUA is posi-tively correlated with BMI, waist circumference, visceral fat area, the ratio of visceral fat area with subcutaneous fat area, fasting plasma glucose, HOMA-IR, serum triglyceride, serum creatinine, systolic and diastolic blood pressure, and the above parameter of correlation coefficient was 0.361, 0.446, 0.634, 0.360, 0.193, 0.287, 0.477, 0.259, 0.280, 0.181, respectively. Stepwise multiple regression analysis showed that visceral fat area, and serum triglyceride were significant explanatory variables for SUA levels, and the standardized regression coefficient was 0.533, 0.183 respectively. Visceral fat accumulation increased significantly with the in-crease of uric acid. A higher quartile of SUA showed a higher visceral fat area (P<0.05). The SUA was significantly higher in metabolic syndrome group than that in the non-metabolic syndrome group (434.6±69.6 umol/l vs 367.0±104.9umol/l, P<0.01). In Spearman rank correlation analysis, the SUA was elevated with increasing metabolic syndrome characteristics (P<0.01). Conclu-sion The present study indicated that SUA is significantly associated with visceral fat accumulation. Patients with metabolic syn-drome revealed a higher SUA.