CAJ | 학술논문

目的：探讨血浆置换术联合丙种球蛋白在治疗神经系统免疫疾病的临床效果。方法选取该院在2010年2月-2014年2月间收治的200例神经系统免疫性疾病患者的临床资料，根据随机分组法原则，将患者平分为两组，每组100例病例。两组患者均接受常规治疗，对照组在常规治疗基础上采用血浆置换治疗，观察组在对照组基础上联合使用丙种球蛋白治疗，对比分析两组患者神经功能评分﹑临床疗效﹑住院时间。结果①观察组中治疗显效患者70例，治疗有效患者25例，总有效率为95%，对照组中治疗显效患者58例，治疗有效患者27例，总有效率为85%。观察组治疗有效率明显优于对照组，对比差异有统计学意义(P<0.05)。②观察组的住院时间低于对照组，神经功能评分优于对照组，差异有统计学意义(P<0.05)。结论血浆置换联合丙种球蛋白在在神经系统免疫性疾病中值得进一步推广﹑研究﹑完善。
목적：탐토혈장치환술연합병충구단백재치료신경계통면역질병적림상효과。방법선취해원재2010년2월-2014년2월간수치적200례신경계통면역성질병환자적림상자료，근거수궤분조법원칙，장환자평분위량조，매조100례병례。량조환자균접수상규치료，대조조재상규치료기출상채용혈장치환치료，관찰조재대조조기출상연합사용병충구단백치료，대비분석량조환자신경공능평분﹑림상료효﹑주원시간。결과①관찰조중치료현효환자70례，치료유효환자25례，총유효솔위95%，대조조중치료현효환자58례，치료유효환자27례，총유효솔위85%。관찰조치료유효솔명현우우대조조，대비차이유통계학의의(P<0.05)。②관찰조적주원시간저우대조조，신경공능평분우우대조조，차이유통계학의의(P<0.05)。결론혈장치환연합병충구단백재재신경계통면역성질병중치득진일보추엄﹑연구﹑완선。
Objective To observe the clinical effect of plasmapheresis combined with gamma globulin in the treatment of neurolog-ical autoimmune diseases. Methods The clinical data of 200 cases with neurological autoimmune diseases admitted in our hospital from February 2010 to February 2014 were selected. And the patients were equally divided into two groups in accordance with the principle of randomization method with 100 patients in each. Based on the conventional treatment, the control group was given the plasmapheresis, and the observation group was given plasmapheresis combined with gamma globulin. And the neurological function score, clinical efficacy, duration of hospitalization were compared and analyzed between the two groups. Results①In the observa-tion group, the treatment was remarkably effective in 70 cases, effective in 25 cases, the total effective rate was 95%, in the control group, the treatment was remarkably effective in 58 cases, and effective in 27 cases, the total effective rate was 85%, the effective rate of the observation group was much better than that of the control group, the comparison was statistically significant (P<0.05).②The duration of hospitalization of the observation group was shorter than that of the control group, the neurological function score was better than that of the control group, the differences were statistically significant (P<0.05). Conclusion Plasmapheresis com-bined with gamma globulin for neurological autoimmune diseases is worthy of further promotion, study and improvement.