CAJ | 학술논문

目的：观察阴虚胃痛颗粒联合三联疗法治疗阴虚型慢性胃炎的临床效果。方法将阴虚型慢性胃炎患者93例随机分为对照组45例和治疗组48例。对照组给予西医克拉霉素片、阿莫西林胶囊及果胶铋胶囊三联疗法治疗，治疗组则在对照组治疗基础上给予中成药阴虚胃痛颗粒治疗，2组均以7 d为1个疗程，治疗6个疗程。观察2组治疗前后临床症状评分情况，用数字疼痛强度评估标尺（ NRS）评判患者治疗前后疼痛情况，比较2组幽门螺杆菌转阴率及临床治疗的有效率。结果2组治疗后胃脘隐痛或灼痛、口干舌燥、大便干结等主要症状积分及疼痛NRS评分均显著下降（P均＜0．05），且治疗组的改善程度均明显优于对照组（ P均＜0．05）；治疗组幽门螺杆菌转阴率为92％，对照组为80％，2组比较差异无统计学意义（P＞0．05）；治疗组临床有效率为92％，对照组为71％，2组比较差异有统计学意义（P＜0．05）。结论阴虚胃痛颗粒治疗慢性胃炎能有效改善患者临床症状，缓解患者的胃痛感，抑制幽门螺杆菌感染，效果显著，值得临床深入研究运用。
목적：관찰음허위통과립연합삼련요법치료음허형만성위염적림상효과。방법장음허형만성위염환자93례수궤분위대조조45례화치료조48례。대조조급여서의극랍매소편、아막서림효낭급과효필효낭삼련요법치료，치료조칙재대조조치료기출상급여중성약음허위통과립치료，2조균이7 d위1개료정，치료6개료정。관찰2조치료전후림상증상평분정황，용수자동통강도평고표척（ NRS）평판환자치료전후동통정황，비교2조유문라간균전음솔급림상치료적유효솔。결과2조치료후위완은통혹작통、구간설조、대편간결등주요증상적분급동통NRS평분균현저하강（P균＜0．05），차치료조적개선정도균명현우우대조조（ P균＜0．05）；치료조유문라간균전음솔위92％，대조조위80％，2조비교차이무통계학의의（P＞0．05）；치료조림상유효솔위92％，대조조위71％，2조비교차이유통계학의의（P＜0．05）。결론음허위통과립치료만성위염능유효개선환자림상증상，완해환자적위통감，억제유문라간균감염，효과현저，치득림상심입연구운용。
Objective It is to investigate the clinical efficacy of Yin deficiency stomach granule and triple therapy on Yin-deficiency type of chronic gastritis.Methods 93 Yin-deficiency type patients with chronic gastritis were randomly divided into a control group of 45 cases and a treatment group of 48 cases.Patients in the control group were treated with conventional west-ern medicine triple therapy, such as clarithromycin tablets and amoxil capsule, colloidal bismuth pectin capsules; while pa-tients in the treatment group were treated with Yin deficiency stomach granule for oral treatment on the basis of foundation treatment, 7 days for a course, six courses for treatment.The improvement of clinical symptoms was observed, and the pain scored in pretherapy and post-treatment were evaluated by NRS, the negative conversion ratio and the effective rate of the two groups were compared.Results The main clinical symptoms of the patients in two groups, such as stomachache, thirsty and dry stool and NRS scores were improved clearly, and the symptom scores went down clearly(P<0.05), the degree of change in the treatment group was more pronounced, the difference is significant ( P<0.05); The negative conversion ratio for pa-tients in the treatment group is 92%, which was higher than that of the control group 80%, the difference was not significant (P>0.05);The efficiency for patients in the treatment group is 92%, while for patients in the control group is 71%.The clinical efficacy of the treatment group was higher than that of the control group, the difference was significant (P<0.05). Conclusion Yin deficiency stomach granule can nourish the stomach Yin and relieve stomachache pain, and inhibit Helico-bacter pylori infection in the treatment for chronic gastritis.It’ s the clinical common Chinese patent medicine for treating Yin deficiency type of chronic gastritis, the clinical effect is significant, and it is worthy of further research and development.