现代医药卫生
現代醫藥衛生
현대의약위생
MODERN MEDICINE HEALTH
2015年
1期
34-35,39
,共3页
王麒竣%曾晓刚%叶嗣宽
王麒竣%曾曉剛%葉嗣寬
왕기준%증효강%협사관
结核,肺%结核,抗多种药物性%肺切除术%药物疗法,联合%治疗结果
結覈,肺%結覈,抗多種藥物性%肺切除術%藥物療法,聯閤%治療結果
결핵,폐%결핵,항다충약물성%폐절제술%약물요법,연합%치료결과
Tuberculosis,pulmonary%Tuberculosis,multidrug-resistant%Pneumonectomy%Drug therapy,combi-nation%Treatment outcome
目的：研究肺切除联合化疗治疗耐多药肺结核的临床效果。方法选择2010年7月至2014年6月在该院接受治疗的耐多药肺结核患者64例，按照掷骰子法分为联合治疗组与对照组各32例。对照组行化疗治疗，联合治疗组在对照组基础上行肺切除术治疗。观察两组患者疗效及并发症发生率。结果联合治疗组治愈率[87.50%（28/32）]、无变化率[6.25%（2/32）]、恶化率[3.13%（1/32）]、病死率[3.13%（1/32）]均优于对照组[37.50%（12/32）、25.00%（8/32）、18.75%（6/32）、18.75%（6/32）]，差异均有统计学意义（P＜0.05）。联合治疗组并发症总发生率[12.50%（4/32）]低于对照组[37.50%（12/32）]，差异有统计学意义（P＜0.05）。结论肺切除联合化疗治疗耐多药肺结核疗效显著，并发症发生率低，是一种较为理想的治疗耐多药肺结核的方法，值得应用于临床。
目的：研究肺切除聯閤化療治療耐多藥肺結覈的臨床效果。方法選擇2010年7月至2014年6月在該院接受治療的耐多藥肺結覈患者64例，按照擲骰子法分為聯閤治療組與對照組各32例。對照組行化療治療，聯閤治療組在對照組基礎上行肺切除術治療。觀察兩組患者療效及併髮癥髮生率。結果聯閤治療組治愈率[87.50%（28/32）]、無變化率[6.25%（2/32）]、噁化率[3.13%（1/32）]、病死率[3.13%（1/32）]均優于對照組[37.50%（12/32）、25.00%（8/32）、18.75%（6/32）、18.75%（6/32）]，差異均有統計學意義（P＜0.05）。聯閤治療組併髮癥總髮生率[12.50%（4/32）]低于對照組[37.50%（12/32）]，差異有統計學意義（P＜0.05）。結論肺切除聯閤化療治療耐多藥肺結覈療效顯著，併髮癥髮生率低，是一種較為理想的治療耐多藥肺結覈的方法，值得應用于臨床。
목적：연구폐절제연합화료치료내다약폐결핵적림상효과。방법선택2010년7월지2014년6월재해원접수치료적내다약폐결핵환자64례，안조척투자법분위연합치료조여대조조각32례。대조조행화료치료，연합치료조재대조조기출상행폐절제술치료。관찰량조환자료효급병발증발생솔。결과연합치료조치유솔[87.50%（28/32）]、무변화솔[6.25%（2/32）]、악화솔[3.13%（1/32）]、병사솔[3.13%（1/32）]균우우대조조[37.50%（12/32）、25.00%（8/32）、18.75%（6/32）、18.75%（6/32）]，차이균유통계학의의（P＜0.05）。연합치료조병발증총발생솔[12.50%（4/32）]저우대조조[37.50%（12/32）]，차이유통계학의의（P＜0.05）。결론폐절제연합화료치료내다약폐결핵료효현저，병발증발생솔저，시일충교위이상적치료내다약폐결핵적방법，치득응용우림상。
Objective To investigate the curative effect of pulmonary resection combined with chemotherapy in treatment of multidrug-resistant tuberculosis. Methods A total of 64 patients with multidrug-resistant tuberculosis treated in this hosptial from July 2010 to June 2014 were selected into the treatment group and the control group by dicing ,each of 32 cases. The patients in the control group were received chemotherapy while conducted pulmonary resection based on the conttrol group. The occur-rence rate of curative effect and complications was observed. Results The treatment group was 87.50%(28/32) in cure rate , 6.25%(2/32) in non-chang rate,3.13%(1/32) in deterioration rate,3.13%(1/32) in mortality rate respectively,all of which was higher thant those of in the control group [37.50%(12/32),25.00%(8/32),18.75%(6/32),18.75%(6/32)]. The difference had statisit-cally significance(P<0.05);The occurrence rate of complications in the treatment group was 12.50%(4/32),which was lower than that in the control group[37.5%(12/32)]. The difference had statistical significance(P<0.05). Conclusion The pulmonary resec-tion combined with chemotherapy in treatment of multidrug-resistant tuberculosis is effective significantly with low occurrence in complications,which is a desired therapeutic method against multidrug-resistant tuberculosis,being worthy to expanding in clinic.
