CAJ | 학술논문

目的：观察肝细胞肝癌（ HCC）组织中肿瘤干细胞标记物CD90的表达变化，并探讨其临床意义。方法采用免疫组化法检测60例HCC组织（ HCC组）、60例癌旁组织（癌旁组）及60例正常肝脏组织（对照组）中的CD90，分析其表达与HCC 临床病理参数的关系。结果 CD90阳性表达率HCC 组为76．7％（46／60）、癌旁组为48．3％（29／60）、对照组为0，3组组间两两比较，P均＜0．01。 CD90表达与HCC患者的性别、民族、有无门静脉瘤栓、包膜是否完整、TMN分期、病理分级有关（P均≤0．05），与HCC患者的年龄、肿瘤大小、甲胎蛋白高低、乙肝病毒是否阳性无关（P均＞0．05）。结论 CD90在HCC组织及癌旁组织中高表达，HCC组织中表达更高；癌组织中CD90表达有助于HCC患者预后的判断，可为患者进行个体化诊断治疗提供参考。
목적：관찰간세포간암（ HCC）조직중종류간세포표기물CD90적표체변화，병탐토기림상의의。방법채용면역조화법검측60례HCC조직（ HCC조）、60례암방조직（암방조）급60례정상간장조직（대조조）중적CD90，분석기표체여HCC 림상병리삼수적관계。결과 CD90양성표체솔HCC 조위76．7％（46／60）、암방조위48．3％（29／60）、대조조위0，3조조간량량비교，P균＜0．01。 CD90표체여HCC환자적성별、민족、유무문정맥류전、포막시부완정、TMN분기、병리분급유관（P균≤0．05），여HCC환자적년령、종류대소、갑태단백고저、을간병독시부양성무관（P균＞0．05）。결론 CD90재HCC조직급암방조직중고표체，HCC조직중표체경고；암조직중CD90표체유조우HCC환자예후적판단，가위환자진행개체화진단치료제공삼고。
Objective To explore the expression and clinical significance of CD 90 in hepatocellular carcinoma .Meth-ods The expression of CD 90 in cancer tissues , para-carcinoma tissues and normal liver tissues were detected by immuno-histochemical method , and to analyze the significance .Results The positive expression rate of CD 90 was 76.7%(46/60) in HCC group, 48.3%(29/60)in paraneoplastic group, 0 in normal group;there were significant differences among three groups (all P<0.01).The expression of CD90 in HCC tissues was correlated with gender , ethnicity, portal vein tumor thrombus, envelope integrity, clinical and pathological staging (all P<0.05); which was not associated with age , tumor size, AFP values and the expression of hepatitis B (all P<0.05).Conclusion The expression of CD90 increased in cancer tissues and para-carcinoma tissues , especially in cancer tissues , which maight be closely related to a poor prognosis of patients with liver cancer .