CAJ | 학술논문

肺移植的长期成功率受到慢性移植物功能障碍的限制,而慢性移植物功能障碍主要原因是闭塞性细支气管炎(obliterative bronchiolitis, OB).OB的机制涉及免疫介导通路(免疫排斥,同种异体免疫机制)和非免疫介导通路(感染、误吸、缺血、原发移植物功能障碍),最终导致纤维增生反应.深入研究OB的机制将为进一步探索OB的治疗方案开辟新的思路.
폐이식적장기성공솔수도만성이식물공능장애적한제,이만성이식물공능장애주요원인시폐새성세지기관염(obliterative bronchiolitis, OB).OB적궤제섭급면역개도통로(면역배척,동충이체면역궤제)화비면역개도통로(감염、오흡、결혈、원발이식물공능장애),최종도치섬유증생반응.심입연구OB적궤제장위진일보탐색OB적치료방안개벽신적사로.
Long-term success in lung transplantation continues to be challenged by chronic graft dysfunction, which is manifest as bronchiolitis obliterans syndrome (BOS). The mechanisms of BOS involve both immune-mediated pathways (rejection, autoimmune-like mechanisms), and alloimmune-independent pathways (infection, aspiration, ischemia, primary graft failure), which lead to a fibroproliferative responses. The further research in pathogenesis of OB after lung transplantation will provide some new ideas of the treatment OB.