山东医药
山東醫藥
산동의약
SHANDONG MEDICAL JOURNAL
2015年
19期
8-10
,共3页
乙型肝炎%肝硬化%肝性脑病%细菌感染
乙型肝炎%肝硬化%肝性腦病%細菌感染
을형간염%간경화%간성뇌병%세균감염
hepatitis B%liver cirrhosis%hepatic encephalopathy%bacterial infections
目的:分析细菌感染诱发肝性脑病的乙型肝炎肝硬化患者的临床特点。方法回顾性分析186例乙型肝炎肝硬化合并肝性脑病患者的临床资料,根据是否存在细菌感染的诱因将患者分为感染组(59例)和非感染组(127例)。观察两组血氨、白蛋白(ALB)、丙氨酸氨基转移酶(ALT)、总胆红素(TBIL)、国际标准化比率(INR)、白细胞(WBC)、中性粒细胞百分比、肌酐(Cr)、病死率。结果感染组血氨(113.7±63.0)μmol/L,ALT(206.3±86.4)U/L,TBIL(113.7±62.9)mmol/L,WBC(11.0±7.3)×109/L,中性粒细胞百分比79.6%±6.6%,Cr(118.2±91.4)μmol/L,Child-Pugh分级(13±1)分,病死率为40.6%。非感染组血氨(80.9±40.7)μmol/L,ALT(114.2±20.9)U/L,TBIL(80.9±40.7)mmol/L,WBC(6.6±4.8)×109/L,中性粒细胞百分比61.4%±6.9%,Cr(72.9±34.3)μmol/L,Child-Pugh分级(10±1)分,病死率为28.3%,两组比较,P均<0.05。结论细菌感染诱发肝性脑病的乙型肝炎肝硬化患者肝损害重,血氨、WBC、中性粒细胞百分比、病死率高。
目的:分析細菌感染誘髮肝性腦病的乙型肝炎肝硬化患者的臨床特點。方法迴顧性分析186例乙型肝炎肝硬化閤併肝性腦病患者的臨床資料,根據是否存在細菌感染的誘因將患者分為感染組(59例)和非感染組(127例)。觀察兩組血氨、白蛋白(ALB)、丙氨痠氨基轉移酶(ALT)、總膽紅素(TBIL)、國際標準化比率(INR)、白細胞(WBC)、中性粒細胞百分比、肌酐(Cr)、病死率。結果感染組血氨(113.7±63.0)μmol/L,ALT(206.3±86.4)U/L,TBIL(113.7±62.9)mmol/L,WBC(11.0±7.3)×109/L,中性粒細胞百分比79.6%±6.6%,Cr(118.2±91.4)μmol/L,Child-Pugh分級(13±1)分,病死率為40.6%。非感染組血氨(80.9±40.7)μmol/L,ALT(114.2±20.9)U/L,TBIL(80.9±40.7)mmol/L,WBC(6.6±4.8)×109/L,中性粒細胞百分比61.4%±6.9%,Cr(72.9±34.3)μmol/L,Child-Pugh分級(10±1)分,病死率為28.3%,兩組比較,P均<0.05。結論細菌感染誘髮肝性腦病的乙型肝炎肝硬化患者肝損害重,血氨、WBC、中性粒細胞百分比、病死率高。
목적:분석세균감염유발간성뇌병적을형간염간경화환자적림상특점。방법회고성분석186례을형간염간경화합병간성뇌병환자적림상자료,근거시부존재세균감염적유인장환자분위감염조(59례)화비감염조(127례)。관찰량조혈안、백단백(ALB)、병안산안기전이매(ALT)、총담홍소(TBIL)、국제표준화비솔(INR)、백세포(WBC)、중성립세포백분비、기항(Cr)、병사솔。결과감염조혈안(113.7±63.0)μmol/L,ALT(206.3±86.4)U/L,TBIL(113.7±62.9)mmol/L,WBC(11.0±7.3)×109/L,중성립세포백분비79.6%±6.6%,Cr(118.2±91.4)μmol/L,Child-Pugh분급(13±1)분,병사솔위40.6%。비감염조혈안(80.9±40.7)μmol/L,ALT(114.2±20.9)U/L,TBIL(80.9±40.7)mmol/L,WBC(6.6±4.8)×109/L,중성립세포백분비61.4%±6.9%,Cr(72.9±34.3)μmol/L,Child-Pugh분급(10±1)분,병사솔위28.3%,량조비교,P균<0.05。결론세균감염유발간성뇌병적을형간염간경화환자간손해중,혈안、WBC、중성립세포백분비、병사솔고。
Objective To analyze the clinical features of hepatic encephalopathy ( HE) induced by bacterial infection in patients with hepatitis B virus ( HBV)-related cirrhosis.Methods A total of 186 cases of patients with HBV-related cirrhosis and HE were divided into the infection group (59 cases) and non-infection group (127 cases) according to wheth-er the presence of bacterial infections.We observed the blood ammonia, serum albumin ( ALB) , alanine aminotransferase ( ALT) , total bilirubin ( TBIL) , international normalized ratio ( INR) , white blood cell ( WBC) , the percentage of neutro-phile granulocyte, serum creatinine ( Cr) and the mortality rate in the two groups.Results In the infection group, ammo-nia was (113.7 ±63.0)μmol/L, ALT was (206.3 ±86.4) U/L, TBIL was (113.7 ±62.9) mmol/L, WBC was (11.0 ±7.3) ×109/L, the percentage of neutrophile granulocyte was 79.6%±6.6%, Cr was (118.2 ±91.4) μmol/L, the Child-Pugh scores were (13 ±1) scores and the mortality rate was 40.6%.In the non-infection group, ammonia was (80.9 ±40.7) μmol/L, ALT was (114.2 ±20.9) U/L, TBIL was (80.9 ±40.7) mmol/L, WBC was (6.6 ±4.8) × 109/L, the percentage of neutrophile granulocyte was 61.4%±6.9%, Cr was (72.9 ±34.3) μmol/L, Child-Pugh scores were (10 ±1) scores and the mortality rate was 28.3%.Significant differences were found in the above indexes between the two groups ( all P<0.05) .Conclusions Serious liver damage is found in patients with HBV-related cirrhosis and HE induced by bacterial infection.Meanwhile, the patients have high ammonia, WBC, the percentage of neutrophile granulo-cyte levels and high mortality rate.