现代中西医结合杂志
現代中西醫結閤雜誌
현대중서의결합잡지
MODERN JOURNAL OF INTEGRATED TRADITIONAL CHINESE AND WESTERN MEDICINE
2015年
16期
1711-1713,1716
,共4页
黄安%史加鑫%徐晶%庞宇舟
黃安%史加鑫%徐晶%龐宇舟
황안%사가흠%서정%방우주
白芍总苷%甲氨蝶呤%幼年特发性关节炎%Meta分析%随机对照试验
白芍總苷%甲氨蝶呤%幼年特髮性關節炎%Meta分析%隨機對照試驗
백작총감%갑안접령%유년특발성관절염%Meta분석%수궤대조시험
total glucosides paeony%methorexate%juvenile idiopathic arthritis%Meta-analysis%randomized controlled trial
目的:系统评价白芍总苷( TGP)联用甲氨蝶呤( MTX)治疗幼年特发性关节炎( JIA)的临床疗效及安全性,为临床用药提供证据。方法计算机检索 Pubmed、CNKI、VIP数据库1989年9月—2014年9月有关TGP联用MTX治疗JIA的随机对照试验( RCT),按照纳入与排除标准筛选出符合要求的RCT,采用RevMan 5.0版软件进行系统评价。结果共纳入4个RCT,合计237例患者,其中试验组120例,对照组117例。 Meta分析结果显示:治疗12周后,TGP联用MTX治疗与单用MTX治疗的总有效率比较差异无统计学意义[ OR=3.75、95%CI(0.63,22.36),P=0.15];而治疗24周后总有效率比较差异有统计学意义[OR=2.03,95%CI(1.04,9.11),P=0.04]。结论 TGP联用MTX治疗JIA较单用MTX治疗能够提高总有效率,一定程度上减轻主要不良反应,从而起到增效减毒的作用。
目的:繫統評價白芍總苷( TGP)聯用甲氨蝶呤( MTX)治療幼年特髮性關節炎( JIA)的臨床療效及安全性,為臨床用藥提供證據。方法計算機檢索 Pubmed、CNKI、VIP數據庫1989年9月—2014年9月有關TGP聯用MTX治療JIA的隨機對照試驗( RCT),按照納入與排除標準篩選齣符閤要求的RCT,採用RevMan 5.0版軟件進行繫統評價。結果共納入4箇RCT,閤計237例患者,其中試驗組120例,對照組117例。 Meta分析結果顯示:治療12週後,TGP聯用MTX治療與單用MTX治療的總有效率比較差異無統計學意義[ OR=3.75、95%CI(0.63,22.36),P=0.15];而治療24週後總有效率比較差異有統計學意義[OR=2.03,95%CI(1.04,9.11),P=0.04]。結論 TGP聯用MTX治療JIA較單用MTX治療能夠提高總有效率,一定程度上減輕主要不良反應,從而起到增效減毒的作用。
목적:계통평개백작총감( TGP)련용갑안접령( MTX)치료유년특발성관절염( JIA)적림상료효급안전성,위림상용약제공증거。방법계산궤검색 Pubmed、CNKI、VIP수거고1989년9월—2014년9월유관TGP련용MTX치료JIA적수궤대조시험( RCT),안조납입여배제표준사선출부합요구적RCT,채용RevMan 5.0판연건진행계통평개。결과공납입4개RCT,합계237례환자,기중시험조120례,대조조117례。 Meta분석결과현시:치료12주후,TGP련용MTX치료여단용MTX치료적총유효솔비교차이무통계학의의[ OR=3.75、95%CI(0.63,22.36),P=0.15];이치료24주후총유효솔비교차이유통계학의의[OR=2.03,95%CI(1.04,9.11),P=0.04]。결론 TGP련용MTX치료JIA교단용MTX치료능구제고총유효솔,일정정도상감경주요불량반응,종이기도증효감독적작용。
Objective It is to get medication proves though the systemic assessment on the clinical efficacy and safety of the total glucosides paeony ( TGP) combined with methorexate ( MTX) in the treatment for juvenile idiopathic arthritis ( JIA) . Mte hods The PubMed, CNKI and VIP database (Sep, 1989-Sep, 2014) were retrieved for the randomized controlled trials ( RCT) of treating JIA by TGP combined with MTX , and then screen out the satisfactory RCT though inclusion and exclusion criteria, which was systematically assessed by RevMan 5.0 software.Results 4 RCT with 237 patients of which 120 in experi-mental group while 117 in control group were totally screened .The results of Meta analysis showed that:12 weeks later, the efficiency variance between the treatment of TGP combined with MTX and MTX only had no statistical significance [ OR=3.75, 95%CI (0.63, 22.36), P=0.15], while it had statistical significance after 24 weeks[OR=2.03,95%CI (1.04,9. 11), P=0.04].Conclusion The treatment of TGP combined with MTX could improve the total efficiency compared with the treatment of MTX only , it could also relieve the adverse reaction partly and strengthen the its effect of reducing toxicity .