CAJ | 학술논문

目的：分析肺炎克雷伯菌临床分布及药敏情况，为临床合理治疗该菌感染提供实验室依据。方法收集重庆医科大学附属第一医院2012年8月至2014年8月住院患者各类标本中分离的肺炎克雷伯菌2884株，对其临床分布及药敏试验结果进行回顾性分析。结果在收集到的临床各种标本中，痰液中肺炎克雷伯杆菌检出率最高，血液检出率最低，主要分布在呼吸内科等各个重症监护病房；产超广谱β-内酰胺酶（ESBLs）肺炎克雷伯菌对氨苄西林耐药率高达100.00%，对其他抗生素也呈不同程度耐药，亚胺培南及含β-内酰胺酶类抑制剂的复方制剂类抗生素是合理有效的治疗药物。结论该院临床分离的肺炎克雷伯菌主要来自痰液，对多种抗菌药物呈耐药倾向，应加强临床标本送检，进行耐药性监测，根据药敏结果合理用药。
목적：분석폐염극뢰백균림상분포급약민정황，위림상합리치료해균감염제공실험실의거。방법수집중경의과대학부속제일의원2012년8월지2014년8월주원환자각류표본중분리적폐염극뢰백균2884주，대기림상분포급약민시험결과진행회고성분석。결과재수집도적림상각충표본중，담액중폐염극뢰백간균검출솔최고，혈액검출솔최저，주요분포재호흡내과등각개중증감호병방；산초엄보β-내선알매（ESBLs）폐염극뢰백균대안변서림내약솔고체100.00%，대기타항생소야정불동정도내약，아알배남급함β-내선알매류억제제적복방제제류항생소시합리유효적치료약물。결론해원림상분리적폐염극뢰백균주요래자담액，대다충항균약물정내약경향，응가강림상표본송검，진행내약성감측，근거약민결과합리용약。
Objective To analyze clinical distribution and drug allergy of klebsiella pneumoniae. To provide laboratory ground for reasonable clinical therapy for this infection. Methods Collected 2 884 strains of klebsiella pneumoniae separated from various kinds of samples of inpatients admitted in the First Affiliated Hospital of Chongqing Medical University from August , 2012 to August,2014 and retrospectively analyzed its clinical distribution and drug snsceptibility test outcomes. Results Among all kinds of samples sputum had the highest klebsiella pneumoniae detection rate ,while blood samples had the lowest. It was mainly distributed in respiratory medicine department and other ICUs. The drug resistance rate of extended spectrum beta-lacta-mases(ESBLs)-producing klebsiella pneumoniae to ampicillin reached up to 100.00%. ESBLs-producing klebsiella pneumoniae had different resistance to other antibiotics. Imipenem and compound preparation antibiotics containing beta-lactam inhibitor were reasonable and effective treatment drugs. Conclusion The main source of clinical separated klebsiella pneumoniae is sputum , and it has drug resistance to various antibacterial drugs. Should strengthen to submitt clinical samples more often and monitor drug resistance. Apply medicine according to drug susceptibility test outcome.