CAJ | 학술논문

目的：探讨维格列汀联合二甲双胍治疗肥胖型2型糖尿病的疗效。方法选取吉林省人民医院内分泌科于2013年1月—2014年12月收治的肥胖型2型糖尿病患者160例，随机分为两组；其中二甲双胍组给予二甲双胍，联合治疗组同时给予维格列汀和二甲双胍；6个月后，比较两组患者BMI、FPG、2hPBG、HbA1c、GLP-1、TC、TG、HDL-C、LDL-C等指标。结果治疗后两组患者的BMI、FPG、2hPBG、HbA1c、TC、TG、LDL-C等指标与治疗前比较明显降低，而GLP-1与HDL-C水平明显升高，差异有统计学意义(P<0.05)；治疗后联合治疗组患者的BMI、FPG、2hPBG、HbA1c、TC、TG、LDL-C等指标与二甲双胍组比较下降更为明显，而GLP-1与HDL-C水平升高更为明显，差异有统计学意义(P<0.05)。结论维格列汀联合二甲双胍治疗肥胖型2型糖尿病疗效明显，值得推广。
목적：탐토유격렬정연합이갑쌍고치료비반형2형당뇨병적료효。방법선취길림성인민의원내분비과우2013년1월—2014년12월수치적비반형2형당뇨병환자160례，수궤분위량조；기중이갑쌍고조급여이갑쌍고，연합치료조동시급여유격렬정화이갑쌍고；6개월후，비교량조환자BMI、FPG、2hPBG、HbA1c、GLP-1、TC、TG、HDL-C、LDL-C등지표。결과치료후량조환자적BMI、FPG、2hPBG、HbA1c、TC、TG、LDL-C등지표여치료전비교명현강저，이GLP-1여HDL-C수평명현승고，차이유통계학의의(P<0.05)；치료후연합치료조환자적BMI、FPG、2hPBG、HbA1c、TC、TG、LDL-C등지표여이갑쌍고조비교하강경위명현，이GLP-1여HDL-C수평승고경위명현，차이유통계학의의(P<0.05)。결론유격렬정연합이갑쌍고치료비반형2형당뇨병료효명현，치득추엄。
Objective To explore the efficacy of vildagliptin combined with metformin in treatment of type 2 diabetes with obesity. Methods Patients (160 cases) who came to endocrinology department of Jilin province people's hospital from January 2013 to December 2014 were randomly divided into two groups; the metformin group was given metformin alone and the combination group was given vildagliptin and metformin; after 6 month, the indexes of two groups such as BMI, FPG, 2hPBG, HbA1c, GLP-1, TC, TG, HDL-C, LDL-C were observed.Results After treatment,compared with that before treatment, BMI, FPG, 2hPBG, HbA1c, TC, TG and LDL-C significantly decreased, and GLP-1, HDL-C significantly increased,the differences were statictically significant(P<0.05); after treatment,BMI, FPG, 2hPBG, HbA1c, TC, TG and LDL-C in combination group dropped off more sharply, and GLP- 1, HDL-C were rise more apparent than those in metformin group,the differences were statictically significant(P<0.05).Conclusion Vildagliptin combined with metformin in treatment of type 2 diabetes with obesity has a better effect, which is worthy of clinical popularization and application.