CAJ | 학술논문

目的：探讨依帕司他对早期糖尿病肾病肾小管功能的作用。方法选取该院于2013年3月—2014年3月收治的糖尿病肾病Ⅲ期患者86例，随机分成两组：治疗组(43例)和对照组(43例)，治疗组在严格控制血糖的基础上加用依帕司他治疗，对照组在严格血糖基础上加用安慰剂治疗。分别治疗6个月后，测定尿α1-微球蛋白(α1-MG)、β2-球蛋白(β2-MG)、视黄醇结合蛋白(RBP)。结果应用依帕司他治疗组肾小管相关指标较对照组均有更明显的好转。结论依帕司他对早期糖尿病肾病肾小管功能损伤有一定的治疗作用。
목적：탐토의파사타대조기당뇨병신병신소관공능적작용。방법선취해원우2013년3월—2014년3월수치적당뇨병신병Ⅲ기환자86례，수궤분성량조：치료조(43례)화대조조(43례)，치료조재엄격공제혈당적기출상가용의파사타치료，대조조재엄격혈당기출상가용안위제치료。분별치료6개월후，측정뇨α1-미구단백(α1-MG)、β2-구단백(β2-MG)、시황순결합단백(RBP)。결과응용의파사타치료조신소관상관지표교대조조균유경명현적호전。결론의파사타대조기당뇨병신병신소관공능손상유일정적치료작용。
Objective To investigate the effect of epalrestat on function of renal tubule in early diabetic nephropathy.Methods 86 cases of patients with diabetic nephropathy stage select the hospital from 2013 march to 2014 march were randomly divided into two groups: treatment group (43 cases) and control group (43 cases), the treatment group based on the strict control of blood glucose plus epalrestat treatment, control group in strict glucose plus placebo treatment. In June after the treatment respectively, the determination of urinary α1- microglobulin (α1-MG), β2- globulin (β2-MG), retinol binding protein (RBP).Results Using epalrestat treatment related indexes of renal tubular compared with the control group showed greater improvement.Conclusion Epalrestat has certain therapeutic effects on renal function injury in early stage of diabetic nephropa.