中外医疗
中外醫療
중외의료
CHINA FOREIGN MEDICAL TREATMENT
2015年
11期
35-37
,共3页
人乳头状瘤病毒%基因型%感染率%年龄分布
人乳頭狀瘤病毒%基因型%感染率%年齡分佈
인유두상류병독%기인형%감염솔%년령분포
Human papilloma virus%Genotype%Infection rates%Age distribution
目的：了解桂林地区高危型人乳头状瘤病毒(HPV)感染及亚型分布情况,为预防子宫颈癌前病变、子宫颈癌提供参考依据。方法采用医用核酸分子快速导流杂交基因芯片技术对2262例妇女进行HPV-DNA基因结果分析。结果2262例妇女中检测出HPV阳性率26.22％,其中高危型感染率较高(19.20％),低危型感染率较低(7.02％)；普通女性中的感染率为18.89％,在宫颈病变患者中的感染率为84.38％,两者相比差异有统计学意义(c2=457.01,P=0.00<0.05)；不同年龄段HPV阳性检出率不同,呈双峰U形曲线,第l峰位于年轻妇女(20~30岁),阳性率为24.61％,第2峰位于中老年妇女(51~65岁),阳性率最高51.74％；高危型主要以HPV52、16、58为主。低危型以HPV6、11最为常见。结论桂林地区2262例女性宫颈HPV感染常见高危型亚型是HPV52、16、58。低危型亚型是HPV6、11。感染年龄趋于年轻化和老年化。桂林地区的HPV感染基因分型符合亚洲人群分布规侓,但有其地区特点。
目的：瞭解桂林地區高危型人乳頭狀瘤病毒(HPV)感染及亞型分佈情況,為預防子宮頸癌前病變、子宮頸癌提供參攷依據。方法採用醫用覈痠分子快速導流雜交基因芯片技術對2262例婦女進行HPV-DNA基因結果分析。結果2262例婦女中檢測齣HPV暘性率26.22％,其中高危型感染率較高(19.20％),低危型感染率較低(7.02％)；普通女性中的感染率為18.89％,在宮頸病變患者中的感染率為84.38％,兩者相比差異有統計學意義(c2=457.01,P=0.00<0.05)；不同年齡段HPV暘性檢齣率不同,呈雙峰U形麯線,第l峰位于年輕婦女(20~30歲),暘性率為24.61％,第2峰位于中老年婦女(51~65歲),暘性率最高51.74％；高危型主要以HPV52、16、58為主。低危型以HPV6、11最為常見。結論桂林地區2262例女性宮頸HPV感染常見高危型亞型是HPV52、16、58。低危型亞型是HPV6、11。感染年齡趨于年輕化和老年化。桂林地區的HPV感染基因分型符閤亞洲人群分佈規侓,但有其地區特點。
목적：료해계임지구고위형인유두상류병독(HPV)감염급아형분포정황,위예방자궁경암전병변、자궁경암제공삼고의거。방법채용의용핵산분자쾌속도류잡교기인심편기술대2262례부녀진행HPV-DNA기인결과분석。결과2262례부녀중검측출HPV양성솔26.22％,기중고위형감염솔교고(19.20％),저위형감염솔교저(7.02％)；보통녀성중적감염솔위18.89％,재궁경병변환자중적감염솔위84.38％,량자상비차이유통계학의의(c2=457.01,P=0.00<0.05)；불동년령단HPV양성검출솔불동,정쌍봉U형곡선,제l봉위우년경부녀(20~30세),양성솔위24.61％,제2봉위우중노년부녀(51~65세),양성솔최고51.74％；고위형주요이HPV52、16、58위주。저위형이HPV6、11최위상견。결론계임지구2262례녀성궁경HPV감염상견고위형아형시HPV52、16、58。저위형아형시HPV6、11。감염년령추우년경화화노년화。계임지구적HPV감염기인분형부합아주인군분포규률,단유기지구특점。
Objective Know guilin area type high-risk human papilloma virus (HPV) infection and subtype distribution, in order to prevent cervical cancer lesion before, and provides some references for the cervical cancer.Methods the medical nucleic acids rapid diversion hybrid gene chip technology on 2262 women in HPV DNA genetic results analysis.Results Detect the HPV positive rate of 26.22%, in 2262 women with high-risk type higher infection rate (19.20%), low-risk type low infection rate (7.02%); Ordinary women in the infection rate was 18.89%, the infection rate was 84.38% in patients with cervical lesions, compared the difference was statistically significant (c2 = 457.01,P= 0.00 < 0.05); Positive rate of HPV was different, different ages shows bimodal u-shaped curve, the first peak in young women l(20~30 years old), positive rate was 24.61%, the second peak is located in the middle-aged and old women (51~ 65 years), the highest positive rate of 51.74%; High-risk type mainly HPV52,16, 58. The most common low-risk type with HPV6 and 11.Conclusion Guilin area 2262 women type cervical HPV infection common high-risk subtype is HPV52, 16, 58. Low-risk type subtype is HPV6, 11. Infection tend to be younger and older age. Genotyping of HPV infection in guilin are in Asian population distribution rules denied, but has its regional characteristics.
