CAJ | 학술논문

目的：探析子宫内膜异位症合并不孕女方内分泌激素水平及自身抗体免疫情况。方法选取该院2012年1月—2014年12月收治的120例子宫内膜异位症(EMS)及不孕症患者,并根据患者疾病类型分为单纯不孕组(A组)38例、单纯子宫内膜异位症组(B组)42例及子宫内膜异位合并不孕症组(AB组)40例,同时选取健康体检者40例,作为对照组,采取化学免疫荧光法测定各组患者血清中的T(睾酮)、INS(胰岛素)、E2(雌二醇)、PRL(泌乳素)、FSH(卵泡刺激素)及LH(黄体生成素)水平,并采取ELISA酶联合免疫法进行测定各组患者AOAb(抗卵巢抗体)、ACAb(抗心磷脂抗体)、ASAb(抗精子抗体)、HCGAb(抗绒毛促性腺激素抗体)及EMAb(抗子宫内膜抗体)阳性情况。结果 AB组患者的PRL、INS、T、E2水平均明显高于A组和B组,差异有统计学意义(P<0.05),FSH及LH水平3组差异无统计学意义(P>0.05),A组和对照组患者的血清PRL水平显著低于B组,差异有统计学意义(P<0.05),其他各指标差异无统计学意义(P>0.05)；AB组的抗体总阳性率明显高于其他3组,差异有统计学意义(P<0.05),A组和B组之间抗体阳性率差异无统计学意义(P>0.05)。结论引起患者发生子宫内膜异位症不孕症的主要因素有可能是子宫内膜异位免疫失衡引起的T、E2、和PRL内分泌异常,通过对其内分泌水平进行分析研究,旨在为临床提供可靠依据。
목적：탐석자궁내막이위증합병불잉녀방내분비격소수평급자신항체면역정황。방법선취해원2012년1월—2014년12월수치적120례자궁내막이위증(EMS)급불잉증환자,병근거환자질병류형분위단순불잉조(A조)38례、단순자궁내막이위증조(B조)42례급자궁내막이위합병불잉증조(AB조)40례,동시선취건강체검자40례,작위대조조,채취화학면역형광법측정각조환자혈청중적T(고동)、INS(이도소)、E2(자이순)、PRL(비유소)、FSH(란포자격소)급LH(황체생성소)수평,병채취ELISA매연합면역법진행측정각조환자AOAb(항란소항체)、ACAb(항심린지항체)、ASAb(항정자항체)、HCGAb(항융모촉성선격소항체)급EMAb(항자궁내막항체)양성정황。결과 AB조환자적PRL、INS、T、E2수평균명현고우A조화B조,차이유통계학의의(P<0.05),FSH급LH수평3조차이무통계학의의(P>0.05),A조화대조조환자적혈청PRL수평현저저우B조,차이유통계학의의(P<0.05),기타각지표차이무통계학의의(P>0.05)；AB조적항체총양성솔명현고우기타3조,차이유통계학의의(P<0.05),A조화B조지간항체양성솔차이무통계학의의(P>0.05)。결론인기환자발생자궁내막이위증불잉증적주요인소유가능시자궁내막이위면역실형인기적T、E2、화PRL내분비이상,통과대기내분비수평진행분석연구,지재위림상제공가고의거。
objective to explore endometriosis merger infertility women autoantibodies immune and endocrine hormone levels. Methods selected our hospital from January 2012 to December 2014 120 examples of intrauterine membrane endometriosis (EMS) and infertility patients, and depending on the type of disease in patients, divided into pure with infertility group (group A), 38 cases, pure endometriosis group (group B) merger of 42 cases of endometriosis and infertility group 40 cases (AB), and 40 cases of healthy check-up, as control group, took chemical immunofluorescence method for determination of T (testosterone) in groups of patients serum, INS (insulin) and E2 (estradiol), PRL (prolactin), FSH (follicle-stimulating hormone) and LH (luteinizing hormone) level, and took with ELISA enzyme immune method for determination of each group were AOAb (ovarian) antibodies, ACAb (anti cardiolipin antibody), ASAb (antisperm antibody), HCGAb (resistance to fluff gonadotropin) antibodies and EMAb (resistance to endometrial antibody) positive. Results patients of group AB with PRL, INS, T, E2 levels were significantly higher than that of group A and group B, the difference was statistically significant(P< 0.05), FSH and LH level difference three groups was not significant(P>0.05), the difference was not statistically significance, group A and the control group in patients with serum PRL level was significantly lower than that of group B(P< 0.05), other indicators has no marked difference(P > 0.05); Antibody total positive rate of group AB was obviously higher than that of the other three groups(P < 0.05), the rate of positive of antibody of differences between group A and group B was not statistically significant(P > 0.05). Conclusion the main factors that cause endometriosis patients with infertility may be due to a endometriosis immune imbalance of T, E2, PRL and endocrine abnormalities, through the analysis of the level of endocrine research, which aims to provide a reliable basis for clinical.