CAJ | 학술논문

目的：探析孕前优生健康检查与出生缺陷预防关系及其在预防出生缺陷方面的效果。方法整群选择2010年1月-2013年12月期间于该院进行孕前优生健康检查355名妇女作为观察组，另以参与调查研究且未行孕前优生健康检查380例妇女作为对照组。为两组孕妇建立档案，对随访情况进行记录，登记妊娠结局、出生缺陷发生率，比较两组出生缺陷发生率。结果观察组出生缺陷发生率为0.3%(1例唇腭裂)，显著低于对照组1.9%(3例唇腭裂、2例神经管畸形、1例先天性心脏病、1例指/趾畸形)，对比差异有统计学意义(P<0.05)。唇腭裂、神经管畸形、先天性心脏病、指(趾)畸形等单项缺陷率的比较差异无统计学意义(P>0.05)。结论孕前优生健康在已婚适龄女性孕产前的应用可有效防治自身疾病，并通过对相关风险因素的干预、评估来避免新生儿出生缺陷情况、最大限度降低新生儿出生缺陷发生率。
목적：탐석잉전우생건강검사여출생결함예방관계급기재예방출생결함방면적효과。방법정군선택2010년1월-2013년12월기간우해원진행잉전우생건강검사355명부녀작위관찰조，령이삼여조사연구차미행잉전우생건강검사380례부녀작위대조조。위량조잉부건립당안，대수방정황진행기록，등기임신결국、출생결함발생솔，비교량조출생결함발생솔。결과관찰조출생결함발생솔위0.3%(1례진악렬)，현저저우대조조1.9%(3례진악렬、2례신경관기형、1례선천성심장병、1례지/지기형)，대비차이유통계학의의(P<0.05)。진악렬、신경관기형、선천성심장병、지(지)기형등단항결함솔적비교차이무통계학의의(P>0.05)。결론잉전우생건강재이혼괄령녀성잉산전적응용가유효방치자신질병，병통과대상관풍험인소적간예、평고래피면신생인출생결함정황、최대한도강저신생인출생결함발생솔。
Objective Analysis of the relationship between pre pregnancy checkups and birth defects prevention and its effect on the prevention of birth defects. Methods 355 women who did pre pregnancy health examination in our hospital from January 2010 to December 2013 as the observation group, the other to participate in investigation of 380 cases of women who not for pre pregnancy health examination as control group. Establish files for two groups of pregnant women, recorded follow-up situation, pregnancy outcome, the incidence of birth defects registration, compared incidence of birth defects of two groups. Results In observation group, the incidence of birth defects was 0.3%(1 cases of cleft lip and palate), was significantly lower than control group of 1.9%(3 cases of cleft lip and palate , 2 cases of neural tube defects, 1 cases of congenital heart disease, 1 cases of finger/toe deformity), difference was statistically significance (P<0.05). The difference of Cleft palate, neural tube defects, congenital heart disease, finger (toe) malformation and other single defect rate showed no statistical significance (P>0.05). Conclusion Using eugenic health before pregnancy in the application of married female school-age pregnancy before can effectively control their disease, through the analysis of the risk factor intervention, evaluate to prevent birth defects in situation, the maximum reduce the incidence of birth defects in newborns.