中外医疗
中外醫療
중외의료
CHINA FOREIGN MEDICAL TREATMENT
2015年
12期
121-122
,共2页
他汀类药物%序贯疗法%心血管疾病%效果观察
他汀類藥物%序貫療法%心血管疾病%效果觀察
타정류약물%서관요법%심혈관질병%효과관찰
Statins%Sequential therapy%Cardiovascular disease%Effect observation
目的：探讨心血管疾病采用他汀类药物序贯疗法治疗临床效果。方法该次随机选取100例心血管疾病患者，均为该院2013年5月-2014年5月收治，随机分组，就标准化用药治疗(对照组，n=50)与加用他汀类药物序贯疗法(观察组，n=50)效果展开对比。结果两组病例治疗前总胆固醇、低密度脂蛋白、三酰甘油差异无统计学意义(P>0.05)，治疗后均有改善(P<0.05)，观察组病例上数各指标改善幅度观察组均优于对照组(P<0.05)。观察组心绞痛1例，心血管事件率为2%；对照组急性血栓事件2例，心源性猝死2例，心肌梗死复发2例，心绞痛复发4例，心血管事件率为20%，差异有统计学意义(P<0.05)。观察组肝功异常7例，对照组无肝功异常发生，差异有统计学意义(P<0.05)。结论他汀类药物序贯疗法治疗心血管疾病，可显著改善患者血脂水平，对稳定病情，促使疾病好转有非常重要的意义，且使心血管不良事件率最大程度降低。临床应用时需针对其肝功能异常不良反应，加强防范，以确保用药安全。
目的：探討心血管疾病採用他汀類藥物序貫療法治療臨床效果。方法該次隨機選取100例心血管疾病患者，均為該院2013年5月-2014年5月收治，隨機分組，就標準化用藥治療(對照組，n=50)與加用他汀類藥物序貫療法(觀察組，n=50)效果展開對比。結果兩組病例治療前總膽固醇、低密度脂蛋白、三酰甘油差異無統計學意義(P>0.05)，治療後均有改善(P<0.05)，觀察組病例上數各指標改善幅度觀察組均優于對照組(P<0.05)。觀察組心絞痛1例，心血管事件率為2%；對照組急性血栓事件2例，心源性猝死2例，心肌梗死複髮2例，心絞痛複髮4例，心血管事件率為20%，差異有統計學意義(P<0.05)。觀察組肝功異常7例，對照組無肝功異常髮生，差異有統計學意義(P<0.05)。結論他汀類藥物序貫療法治療心血管疾病，可顯著改善患者血脂水平，對穩定病情，促使疾病好轉有非常重要的意義，且使心血管不良事件率最大程度降低。臨床應用時需針對其肝功能異常不良反應，加彊防範，以確保用藥安全。
목적：탐토심혈관질병채용타정류약물서관요법치료림상효과。방법해차수궤선취100례심혈관질병환자，균위해원2013년5월-2014년5월수치，수궤분조，취표준화용약치료(대조조，n=50)여가용타정류약물서관요법(관찰조，n=50)효과전개대비。결과량조병례치료전총담고순、저밀도지단백、삼선감유차이무통계학의의(P>0.05)，치료후균유개선(P<0.05)，관찰조병례상수각지표개선폭도관찰조균우우대조조(P<0.05)。관찰조심교통1례，심혈관사건솔위2%；대조조급성혈전사건2례，심원성졸사2례，심기경사복발2례，심교통복발4례，심혈관사건솔위20%，차이유통계학의의(P<0.05)。관찰조간공이상7례，대조조무간공이상발생，차이유통계학의의(P<0.05)。결론타정류약물서관요법치료심혈관질병，가현저개선환자혈지수평，대은정병정，촉사질병호전유비상중요적의의，차사심혈관불량사건솔최대정도강저。림상응용시수침대기간공능이상불량반응，가강방범，이학보용약안전。
Objective To discuss the clinical effect statins sequential therapy in the treatment of cardiovascular disease. Methods 100 cases with cardiovascular disease, who received treatment in our hospital between May 2013 and May 2014 were randomly di-vided into control group (n=50) and observation group (n=50).standardized medication was performed in the control group, while standardized medication combined with statins sequential therapy was performed in the observation group, the effect was compared between the two groups. Results Total cholesterol, low density lipoprotein, three glycerol no significant difference between the two groups before treatment (P﹤0.05), were improved after treatment (P﹤ 0.05), the observation group the number of cases on each index improvement in observation group than in control group (P﹤0.05). The observation group of 1 cases of angina pectoris, car-diovascular event rate was 2%; the control group of 2 cases of acute thrombotic events, sudden cardiac death in 2 cases, 2 cases of myocardial infarction recurrence, 4 cases ofrecurrent angina, cardiac event rate was 20%, there were significant differences (P﹤0.05). The observation group of 7 cases of abnormal liver function, the control group had no abnormal liver function occurred, there were significant differences (P﹤0.05). Conclusion Statins sequential therapy in the treatment of cardiovascular diseases, can im-prove the blood lipid levels and relief the disease significantly and lower furthest the MACE. To ensure the medication safety, it is necessary to supervise the liver function when it is used.
