CAJ | 학술논문

目的：观察比较右丙亚胺注射液单用，参麦注射液单用及右丙亚胺参麦注射液联合使用对急性白血病患者化疗期间心脏毒性的影响。方法将2010年1月-2014年6月该院收治的105例已明确诊断为急性白血病的患者随机分为3组，每组35例。每组患者均应用含有蒽环类药物的化疗方案。A组：右丙亚胺组，在应用蒽环类药物化疗前30 min将右丙亚胺注射液快速静脉滴注。 B组：参麦注射液组，对化疗患者给予参麦注射液保护心脏治疗，用法为50 mg/d静脉滴注。 C组：联合用药组，化疗同时联合应用右丙亚胺及参麦注射液保护心脏。每组药物均在化疗期间使用，化疗结束后停止使用。观察并记录3组患者心肌酶数值变化，心电图改变及左心室射血分数的变化。结果比较3组患者化疗前后的心电图变化，心肌酶变化及左心室射血分数变化，观察其心脏损害的程度及比例。结果表明C组患者各种心脏损害的指标均低于A,B两组。结论右丙亚胺及参麦注射液联合应用对于接受以蒽环类药物为基础的化疗方案的患者，可明显减轻其心脏毒性作用，可作为降低蒽环类药物心脏毒性的新途径。
목적：관찰비교우병아알주사액단용，삼맥주사액단용급우병아알삼맥주사액연합사용대급성백혈병환자화료기간심장독성적영향。방법장2010년1월-2014년6월해원수치적105례이명학진단위급성백혈병적환자수궤분위3조，매조35례。매조환자균응용함유은배류약물적화료방안。A조：우병아알조，재응용은배류약물화료전30 min장우병아알주사액쾌속정맥적주。 B조：삼맥주사액조，대화료환자급여삼맥주사액보호심장치료，용법위50 mg/d정맥적주。 C조：연합용약조，화료동시연합응용우병아알급삼맥주사액보호심장。매조약물균재화료기간사용，화료결속후정지사용。관찰병기록3조환자심기매수치변화，심전도개변급좌심실사혈분수적변화。결과비교3조환자화료전후적심전도변화，심기매변화급좌심실사혈분수변화，관찰기심장손해적정도급비례。결과표명C조환자각충심장손해적지표균저우A,B량조。결론우병아알급삼맥주사액연합응용대우접수이은배류약물위기출적화료방안적환자，가명현감경기심장독성작용，가작위강저은배류약물심장독성적신도경。
Objective To observe and compare the single use of dexrazoxane injection, Shenmai injection alone and dexrazoxane Shenmai injection combined with the use of the effect of cardiac toxicity in cancer patients during chemotherapy. Methods 105 cases who had been diagnosed as acute leukemia patients in our hospital from January 2010 to June 2014,were randomly divided into three groups,35 patients in each group. Patients in each group were applied the chemotherapy regimens containing anthracy-clines. Group A:dexrazoxane group.30 minutes before applying anthracycline chemotherapy to dexrazoxane rapid intravenous in-jection. Group B:Shenmai injection group. Given Shenmai injection to protect the heart treatment on patients with chemotherapy, and the usage is the daily intravenous infusion of 50mg.Group C:the combination group. Chemotherapy combined with dexrazoxane and Shenmai injection to protect the heart.Each group of drugs were used during chemotherapy,and after chemotherapy to stop us-ing. Observe and record changes in three groups of patients'cardiac enzyme values, ECG and the left ventricular ejection fraction. Results To Compare the changes about ECG,cardiac enzyme and the left ventricular ejection fraction of the three groups of pa-tients before and after chemotherapy,and observe the heart damage degree and the ratio.The results show that the group C patients with various heart damage index were lower than those of A, B. Conclusion Dexrazoxane combined with Shenmai injection for pa-tients receiving anthracycline-based chemotherapy regimens, can significantly reduce their cardiac toxicity,and be used as a new way to reduce the anthracycline cardiotoxicity.