中外医疗
中外醫療
중외의료
CHINA FOREIGN MEDICAL TREATMENT
2015年
12期
107-108
,共2页
乙肝病毒%慢加急性肝功能衰竭%拉米夫定%恩替卡韦%效果
乙肝病毒%慢加急性肝功能衰竭%拉米伕定%恩替卡韋%效果
을간병독%만가급성간공능쇠갈%랍미부정%은체잡위%효과
Hepatitis B virus%Acute on chronic liver failure%Lamivudine%Entecavir%Effect
目的：研究拉米夫定与恩替卡韦对比治疗乙肝病毒所致慢加急性肝功能衰竭的效果。方法将乙肝病毒所致慢加急性肝功能衰竭297例分为2组，观察组行恩替卡韦治疗，对照组行拉米夫定治疗。结果2组治疗前后ALB、TBIL、PTA、ALT差异有统计学意义(P<0.05)，观察组总有效率(96.64%)高于对照组(79.73%)，其治疗后4周、12周、48周转阴率(78.52%、87.25%、96.64%)高于对照组(48.65%、64.19%、79.73%)，2组差异有统计学意义(P<0.05)。结论恩替卡韦治疗乙肝病毒所致慢加急性肝功能衰竭的效果优于拉米夫定，近期疗效明显，转阴率高。
目的：研究拉米伕定與恩替卡韋對比治療乙肝病毒所緻慢加急性肝功能衰竭的效果。方法將乙肝病毒所緻慢加急性肝功能衰竭297例分為2組，觀察組行恩替卡韋治療，對照組行拉米伕定治療。結果2組治療前後ALB、TBIL、PTA、ALT差異有統計學意義(P<0.05)，觀察組總有效率(96.64%)高于對照組(79.73%)，其治療後4週、12週、48週轉陰率(78.52%、87.25%、96.64%)高于對照組(48.65%、64.19%、79.73%)，2組差異有統計學意義(P<0.05)。結論恩替卡韋治療乙肝病毒所緻慢加急性肝功能衰竭的效果優于拉米伕定，近期療效明顯，轉陰率高。
목적：연구랍미부정여은체잡위대비치료을간병독소치만가급성간공능쇠갈적효과。방법장을간병독소치만가급성간공능쇠갈297례분위2조，관찰조행은체잡위치료，대조조행랍미부정치료。결과2조치료전후ALB、TBIL、PTA、ALT차이유통계학의의(P<0.05)，관찰조총유효솔(96.64%)고우대조조(79.73%)，기치료후4주、12주、48주전음솔(78.52%、87.25%、96.64%)고우대조조(48.65%、64.19%、79.73%)，2조차이유통계학의의(P<0.05)。결론은체잡위치료을간병독소치만가급성간공능쇠갈적효과우우랍미부정，근기료효명현，전음솔고。
Objective To compare the effects of lamivudine with that of entecavir in the treatment of Acute on chronic liver fail-ure caused by HBV. Methods The hepatitis B virus-induced acute on chronic liver failure 297 cases were divided into two groups, the observation group line entecavir treatment, the control group underwent lamivudine. Results The two groups before and after treatment ALB, TBIL, PTA, ALT difference was statistically significant (P<0.05), the total efficiency of the observation group (96.64%) was higher (79.73%), four weeks after the treatment, 12 weeks , 48 weeks negative rate (78.52%, 87.25%, 96.64%) was higher (48.65%, 64.19%, 79.73%), two groups was statistically significant (P<0.05). Conclusion Entecavir treatment of hepatitis B virus-induced acute on chronic liver failure is better than lamivudine, obvious curative effect, negative rate.
