CAJ | 학술논문

目的：分析及评价卡培他滨联合多西他赛治疗蒽环类耐药性乳腺癌的疗效和不良反应。方法将42例晚期乳腺癌患者随机分为2组，联合组采用卡培他滨联合多西他赛进行治疗。对照组采用多西他赛单药治疗。每2周期评价疗效。结果联合组有效率(CR+PR)为61.9%，主要不良反应为骨髓抑制、手足综合征、消化道反应。对照组有效率(CR+PR)为42.9%，主要不良反应为骨髓抑制、消化道反应等。2组有效率差异有统计学意义(P<0.05)。结论卡培他滨联合多西他赛治疗复发转移性蒽环类耐药的乳腺癌疗效较好，优于单一多西他赛治疗，不良反应可以耐受。
목적：분석급평개잡배타빈연합다서타새치료은배류내약성유선암적료효화불량반응。방법장42례만기유선암환자수궤분위2조，연합조채용잡배타빈연합다서타새진행치료。대조조채용다서타새단약치료。매2주기평개료효。결과연합조유효솔(CR+PR)위61.9%，주요불량반응위골수억제、수족종합정、소화도반응。대조조유효솔(CR+PR)위42.9%，주요불량반응위골수억제、소화도반응등。2조유효솔차이유통계학의의(P<0.05)。결론잡배타빈연합다서타새치료복발전이성은배류내약적유선암료효교호，우우단일다서타새치료，불량반응가이내수。
Objective To research the efficacy and toxicities of capecitabine combined with docetaxel in the treatment of metastatic breast cancer. Methods 42 patients with metastatic breast cancer were randomly divided into two groups. In the combining group,21 patients were treated with capecitabine and docetaxel combination regimen. In the control group, 21 patients were treated with docetaxel. Results In the combining group, the effective rate was 61.9%.The main toxic reactions were myelosuppression, hand-foot syndrome, baldness and gastrointestinal toxicities. In the control group, the effective rate was 42.9%. The main toxic reactions were myelosuppression, baldness and gastrointestinal toxicities. There were statistical difference (P<0.05). Conclusion Good clinical efficacy were achieved in the therapy of metastaticbreast cancer with capecitabine and docetaxel combination regimen and toxic reaction were tolerable.