中外医疗
中外醫療
중외의료
CHINA FOREIGN MEDICAL TREATMENT
2015年
12期
93-94
,共2页
孙衍%王彦%夏星霞%贺娅莎
孫衍%王彥%夏星霞%賀婭莎
손연%왕언%하성하%하아사
小剂量胰岛素%儿童%糖尿病酮症酸中毒%临床疗效
小劑量胰島素%兒童%糖尿病酮癥痠中毒%臨床療效
소제량이도소%인동%당뇨병동증산중독%림상료효
Small doses of insulin%Children%Diabetic ketoacidosis%Clinical effect
目的：研究小剂量胰岛素联合电解质补充治疗儿童糖尿病酮症酸中毒的临床疗效。方法以该院2012年5月-2014年5月收治的30例糖尿病酮症酸中毒患儿为研究对象，均接受小剂量胰岛素、电解质补充等治疗，统计患儿酸中毒纠正时间、住院时间，同时比较治疗前后患儿血糖、钠、钾水平及主要血清炎症因子变化。结果治疗后患儿病情均稳定，平均酸中毒纠正时间、平均住院时间分别为(13.50±1.12)、(14.00±1.05)d。治疗前后患儿血糖[(38.66±2.37)VS(12.07±2.85)]mmol/L、血钾[(5.52±0.81)VS(4.70±0.78)]mmol/L、血钠[(133.27±10.41)VS(142.68±9.98)]mmol/L比较差异有统计学意义(P<0.01)。另外，治疗前后IL-6、IL-12、IL-18及TNF-α水平比较差异有统计学意义(P<0.01)。结论小剂量胰岛素联合电解质补充治疗能明显改善患儿高血糖、高血酮症状，安全有效，可作为儿童糖尿病酮症酸中毒治疗的重要手段。
目的：研究小劑量胰島素聯閤電解質補充治療兒童糖尿病酮癥痠中毒的臨床療效。方法以該院2012年5月-2014年5月收治的30例糖尿病酮癥痠中毒患兒為研究對象，均接受小劑量胰島素、電解質補充等治療，統計患兒痠中毒糾正時間、住院時間，同時比較治療前後患兒血糖、鈉、鉀水平及主要血清炎癥因子變化。結果治療後患兒病情均穩定，平均痠中毒糾正時間、平均住院時間分彆為(13.50±1.12)、(14.00±1.05)d。治療前後患兒血糖[(38.66±2.37)VS(12.07±2.85)]mmol/L、血鉀[(5.52±0.81)VS(4.70±0.78)]mmol/L、血鈉[(133.27±10.41)VS(142.68±9.98)]mmol/L比較差異有統計學意義(P<0.01)。另外，治療前後IL-6、IL-12、IL-18及TNF-α水平比較差異有統計學意義(P<0.01)。結論小劑量胰島素聯閤電解質補充治療能明顯改善患兒高血糖、高血酮癥狀，安全有效，可作為兒童糖尿病酮癥痠中毒治療的重要手段。
목적：연구소제량이도소연합전해질보충치료인동당뇨병동증산중독적림상료효。방법이해원2012년5월-2014년5월수치적30례당뇨병동증산중독환인위연구대상，균접수소제량이도소、전해질보충등치료，통계환인산중독규정시간、주원시간，동시비교치료전후환인혈당、납、갑수평급주요혈청염증인자변화。결과치료후환인병정균은정，평균산중독규정시간、평균주원시간분별위(13.50±1.12)、(14.00±1.05)d。치료전후환인혈당[(38.66±2.37)VS(12.07±2.85)]mmol/L、혈갑[(5.52±0.81)VS(4.70±0.78)]mmol/L、혈납[(133.27±10.41)VS(142.68±9.98)]mmol/L비교차이유통계학의의(P<0.01)。령외，치료전후IL-6、IL-12、IL-18급TNF-α수평비교차이유통계학의의(P<0.01)。결론소제량이도소연합전해질보충치료능명현개선환인고혈당、고혈동증상，안전유효，가작위인동당뇨병동증산중독치료적중요수단。
Objective To study the therapeutic effect of small dose insulin combined with electrolyte in the treatment of Diabetic Ketoacidosis in Children. Methods 30 cases of diabetic ketoacidosis in children were treated in our hospital from May 2012 to May 2014 as the research object, were treated with small dose of insulin, electrolyte supplement statistical treatment, correcting acidosis in children with time, hospitalization time, and compare the changes before and after treatment in children with blood glu-cose, sodium, potassium and the level of serum inflammatory factor mainly. Results After treatment, children with disease were sta-ble, the average correcting acidosis time, average hospitalization time were (13.50±1.12) d, (14.00±1.05) d. Before and after treat-ment in children with blood sugar [(38.66±2.37) VS (12.07±2.85)]mmol/L, blood potassium [(5.52±0.81) VS (4.70±0.78)]mmol/L, blood sodium [(133.27±10.41) VS (142.68± 9.98)]mmol/L, differences were significant (P< 0.01). In addition, differences of IL-6, IL-12, IL-18 and TNF-alpha level were statistical significance before and after treatment (P<0.01). Conclusion Small dose in-sulin combined with electrolyte supplementation can significantly improve the children with high blood sugar, high blood ketone symptoms, safe and effective, can be used as an important means in treatment of children with diabetic ketoacidosis.
