CAJ | 학술논문

目的：探讨术前介入化疗对局部晚期宫颈癌的近期疗效。方法选取入该院治疗的局部晚期宫颈癌患者80例作为研究对象，根据患者意愿分为对照组和观察组，对照组予以根治术治疗，观察组予以术前介入化疗联合根治术治疗，记录手术时间、术中出血量、平均住院时间，记录两组淋巴结转移情况、宫颈浸润深度、切缘阳性情况及术后并发症发生率。结果观察组手术时间、术中出血量及住院时间分别为(165.26±12.84)min、(442.36±26.39)mL、(21.63±4.92)d显著低于对照组，差异有统计学意义(P<0.05)。观察组盆腔淋巴结转移和宫颈浸润深度>1/2的几率分别为7.5%、10.0%显著低于对照组25.0%、30.0%，差异有统计学意义(P<0.05)。观察组术后并发症发生率为12.5%明显低于对照组32.5%，差异有统计学意义(P<0.05)。结论术前介入化疗可缩小局部病灶，抑制盆腔淋巴结转移，有利于降低手术难度。
목적：탐토술전개입화료대국부만기궁경암적근기료효。방법선취입해원치료적국부만기궁경암환자80례작위연구대상，근거환자의원분위대조조화관찰조，대조조여이근치술치료，관찰조여이술전개입화료연합근치술치료，기록수술시간、술중출혈량、평균주원시간，기록량조림파결전이정황、궁경침윤심도、절연양성정황급술후병발증발생솔。결과관찰조수술시간、술중출혈량급주원시간분별위(165.26±12.84)min、(442.36±26.39)mL、(21.63±4.92)d현저저우대조조，차이유통계학의의(P<0.05)。관찰조분강림파결전이화궁경침윤심도>1/2적궤솔분별위7.5%、10.0%현저저우대조조25.0%、30.0%，차이유통계학의의(P<0.05)。관찰조술후병발증발생솔위12.5%명현저우대조조32.5%，차이유통계학의의(P<0.05)。결론술전개입화료가축소국부병조，억제분강림파결전이，유리우강저수술난도。
Objective To explore the short term clinical observation of preoperative interventional chemotherapy on locally ad-vanced cervical cancer. Methods 80 cases of patients with locally advanced cervical cancer were treated in our hospital for treat-ment as the research object, according to the wishes of patients were randomly divided into control group and observation group, control group was given radical surgery treatment, observation group was given preoperative interventional chemotherapy combined with radical operation in the treatment of bleeding, recorded operation time, intraoperative volume, average hospitalization time, recorded lymph cervical node metastasis, depth of invasion, the incidence of positive margin and postoperative complications of two groups. Results In observation group, operation time, amount of bleeding during the operation and hospitalization time were (165.26±12.84) min, (442.36 ±26.39) mL, (21.63±4.92)d, were significantly lower than control group, the differences were statisti-cally significant (P<0.05). The pelvic lymph node metastasis and the chance of invasive cervical depth> 1/2 in observation group were respectively 7.5% and 10%, were significantly lower than the control group of 25%, 30%, the differences were statistically significant(P<0.05). The incidence rate in observation group was 12.5%, was lower than that of control group of 32.5%, the differ-ences were statistically significant (P<0.05). Conclusion Preoperative induced evolution can reduce the local lesion, inhibition of pelvic lymph node metastasis, which helps to reduce the operation difficulty.