CAJ | 학술논문

目的：探讨唑来膦酸联合放疗治疗肺癌骨转移的效果。方法整群选择64例肺癌骨转移患者随机分为观察组与对照组，每组32例。对照组给予放射治疗使用30 Gy/10次或40 Gy/20次剂量进行常规分割放疗，5次/周，4周为1周期。观察组在此基础上同时给予唑来膦酸4 mg+0.9%氯化钠溶液100 mL，静脉滴注15 min，每4周1次，连用3次。结果观察组疼痛缓解率达87.5%远高于对照组的62.5%，差异有统计学意义(P<0.05)；其生存质量改善率为84.38%远高于对照组的56.25%，差异有统计学意义(P<0.05)；两组患者治疗后未出现严重不良反应，发生率差异无统计学意义(P>0.05)。结论唑来膦酸联合放疗治疗肺癌骨转移疗效显著，不良反应小，操作性强，安全方便，值得临床研究推广。
목적：탐토서래련산연합방료치료폐암골전이적효과。방법정군선택64례폐암골전이환자수궤분위관찰조여대조조，매조32례。대조조급여방사치료사용30 Gy/10차혹40 Gy/20차제량진행상규분할방료，5차/주，4주위1주기。관찰조재차기출상동시급여서래련산4 mg+0.9%록화납용액100 mL，정맥적주15 min，매4주1차，련용3차。결과관찰조동통완해솔체87.5%원고우대조조적62.5%，차이유통계학의의(P<0.05)；기생존질량개선솔위84.38%원고우대조조적56.25%，차이유통계학의의(P<0.05)；량조환자치료후미출현엄중불량반응，발생솔차이무통계학의의(P>0.05)。결론서래련산연합방료치료폐암골전이료효현저，불량반응소，조작성강，안전방편，치득림상연구추엄。
Objective To explore the effect of Zoledronic acid combined with radiotherapy in treatment of bone metastases of lung cancer. Methods 64 cases were randomly divided into observer group and control group. The control group was given radiotherapy. Meanwhile,the observer group was given zoledronic acid (4mg, iv). The efficacy of treatment was compared between two groups. Results The pain relief rates of the observer group was 87.5%higher than the control group (62.5%);The rates of life quality im-provement was 84.38%higher than the control group with 56.25%. incidence rate of adverse reactions was not significant. Conclusion Zoledronic acid combined with radiotherapy for bone metastasis in lung cancer patients was more effective than radio-therapy alone.