CAJ | 학술논문

目的：探讨糖皮质激素防止过敏性紫癜肾脏受累的临床应用。方法整群选取该院2012年1-12月间收治的85例早期过敏性紫癜(入院检查，血压、肾功能、尿常规均正常)患儿，分为GCS组与对照组，两组患儿入院后均需要卧床休息，根据患儿具体病因实施治疗，并对患者采取抗过敏与并发症相关预防措施，GCS组患儿增加口服醋酸泼尼松治疗，所有45例患者均随访1年，观察治疗结果。结果两组患儿皮疹消失时间对比，差异无统计学意义(P>0.05)，但是关节痛消失与腹痛消失GCS组均短于对照组，差异无统计学意义(P>0.05)；8、24、48周肾脏受累差异有统计学意义(P<0.05)；GCS组患儿存在不良反应，但随访一年两组患儿体重、身高差异无统计学意义(P>0.05)。结论采用GCS治疗HSP并不会影响患儿发育，但是会导致患儿甘油三脂与总肝固醇水平轻微上升，虽然其远期影响未知，但临床总体效果研究较为明显。
목적：탐토당피질격소방지과민성자전신장수루적림상응용。방법정군선취해원2012년1-12월간수치적85례조기과민성자전(입원검사，혈압、신공능、뇨상규균정상)환인，분위GCS조여대조조，량조환인입원후균수요와상휴식，근거환인구체병인실시치료，병대환자채취항과민여병발증상관예방조시，GCS조환인증가구복작산발니송치료，소유45례환자균수방1년，관찰치료결과。결과량조환인피진소실시간대비，차이무통계학의의(P>0.05)，단시관절통소실여복통소실GCS조균단우대조조，차이무통계학의의(P>0.05)；8、24、48주신장수루차이유통계학의의(P<0.05)；GCS조환인존재불량반응，단수방일년량조환인체중、신고차이무통계학의의(P>0.05)。결론채용GCS치료HSP병불회영향환인발육，단시회도치환인감유삼지여총간고순수평경미상승，수연기원기영향미지，단림상총체효과연구교위명현。
Objective To discuss clinical application on corticosteroids to prevent allergic purpura with renal involvement. Methods Collected from January to December of 2012 Patients (admitted check, blood pressure, and kidney function, and urine General are normal) which had allergic purpura with renal involvement in our hospital for the study, 85 cases divided into GCS group and con-trol group. Both patients had bed rest after hospitalized, implemented treatment according to patients pathogeny, took action to pa-tients for preventive measures on anti-allergic and related complications, GCS group children increased oral acetate poured pred-nisone treatment, all 45 cases were followed for 1 year. Results Compared with rash disappeared time, no statistics sense (P>0.05), but joint pain disappeared and abdominal pain disappeared , GCS group are shorter than control group, had statistics sense (P>0.05); 8, 24, and 48 week kidney involvement are has statistics sense (P<0.05);GCS children exists bad reaction, but followed 1 year, both groups children weight and height had no obvious differences (P>0.05).Conclusion GCS treatment do not affect chil-dren growth, but it lead to liver triglyceride and total cholesterol levels in children with increased slightly, although its long-term effects is unknown, but overall effect in clinical research is quite obvious.