中外医疗
中外醫療
중외의료
CHINA FOREIGN MEDICAL TREATMENT
2015年
13期
129-131
,共3页
孟鲁司特纳%小儿咳嗽变异性哮喘%临床研究
孟魯司特納%小兒咳嗽變異性哮喘%臨床研究
맹로사특납%소인해수변이성효천%림상연구
Montelukast%Children Cough Variant Asthma%Clinical Observation
目的：探讨孟鲁司特纳治疗小儿咳嗽变异性哮喘的临床效果。方法将就诊于该院的75例咳嗽变异性哮喘患儿按照随机数字表法分为对照组37例和观察组38例。对照组患儿单纯给予沙丁胺醇0.25 mL雾化吸入；观察组患者则联合给予孟鲁司特钠咀嚼片口服，连续治疗2个月。观察患儿咳嗽的缓解情况，计算临床治疗的有效率；记录两组患儿咳嗽的消失时间；检测患儿血清炎性细胞因子水平的变化情况，随访3个月观察复发率。结果观察组患儿的有效率92.1%明显高于对照组的有效率73%(P<0.05)；观察组患儿的咳嗽消失时间较对照组患儿更快(P<0.05)；两组患儿炎性细胞因子白细胞介素-6(IL-6)、肿瘤坏死因子(TNF-α)较治疗前降低明显，观察组患儿的降低程度较对照组更突出(P<0.05)；观察组患儿的复发率5.3%明显低于对照组的复发率8.1%(P>0.05)。结论孟鲁司特纳治疗CVA疗效确切，能有效缩短病程，抗炎作用明显，值得临床推广。
目的：探討孟魯司特納治療小兒咳嗽變異性哮喘的臨床效果。方法將就診于該院的75例咳嗽變異性哮喘患兒按照隨機數字錶法分為對照組37例和觀察組38例。對照組患兒單純給予沙丁胺醇0.25 mL霧化吸入；觀察組患者則聯閤給予孟魯司特鈉咀嚼片口服，連續治療2箇月。觀察患兒咳嗽的緩解情況，計算臨床治療的有效率；記錄兩組患兒咳嗽的消失時間；檢測患兒血清炎性細胞因子水平的變化情況，隨訪3箇月觀察複髮率。結果觀察組患兒的有效率92.1%明顯高于對照組的有效率73%(P<0.05)；觀察組患兒的咳嗽消失時間較對照組患兒更快(P<0.05)；兩組患兒炎性細胞因子白細胞介素-6(IL-6)、腫瘤壞死因子(TNF-α)較治療前降低明顯，觀察組患兒的降低程度較對照組更突齣(P<0.05)；觀察組患兒的複髮率5.3%明顯低于對照組的複髮率8.1%(P>0.05)。結論孟魯司特納治療CVA療效確切，能有效縮短病程，抗炎作用明顯，值得臨床推廣。
목적：탐토맹로사특납치료소인해수변이성효천적림상효과。방법장취진우해원적75례해수변이성효천환인안조수궤수자표법분위대조조37례화관찰조38례。대조조환인단순급여사정알순0.25 mL무화흡입；관찰조환자칙연합급여맹로사특납저작편구복，련속치료2개월。관찰환인해수적완해정황，계산림상치료적유효솔；기록량조환인해수적소실시간；검측환인혈청염성세포인자수평적변화정황，수방3개월관찰복발솔。결과관찰조환인적유효솔92.1%명현고우대조조적유효솔73%(P<0.05)；관찰조환인적해수소실시간교대조조환인경쾌(P<0.05)；량조환인염성세포인자백세포개소-6(IL-6)、종류배사인자(TNF-α)교치료전강저명현，관찰조환인적강저정도교대조조경돌출(P<0.05)；관찰조환인적복발솔5.3%명현저우대조조적복발솔8.1%(P>0.05)。결론맹로사특납치료CVA료효학절，능유효축단병정，항염작용명현，치득림상추엄。
Objective To investigate the clinical efficacy of treating Children cough variant asthma with montelukast. Methods 75 Cough Variant Asthma with Montelukast Children were randomly divided into a control group of 37cases and an observation group of 38cases. Patients in the control group were treated with 0.25 mL salbutamol for aerosol inhalation,2times/day,7-10 days for a course; while patients in the observation group were treated with montelukast sodium chewable tablets, 1time/day,2 months for treatment. We observed the improvement of cough symptom and calculated the effective clinical treatment; We recorded the disap-pearance time of cough and tested the level change of serum inflammatory cytokines. We observed the recurrence rate follow-up of 3 months. Results The efficiency for patients in the observation group is92.1%, which was higher than that in the control group 73%(P<0.05);The patients' disappearance time of cough in the observation group was quicker than that in the control group (P<0.05);The level of IL-6、TNF-αin the two groups was lower than before treatment, the degree of change in the observation group was more pronounced (P<0.05);The recurrence rate for patients in the observation group is5.3%, which was lower than that in the control group 8.1% (P>0.05). Conclusion Treating Children cough variant asthma with montelukast has definite curative effect. The therapy can effectively shorten the duration of symptoms, which has a significant anti-inflammatory effect, is worthy of further research and development.
