CAJ | 학술논문

目的：探讨血清嗜酸性粒细胞趋化因子在儿童支气管哮喘患者中的变化及意义。方法：应用ELISA法测定44例儿童支气管哮喘以及37例正常儿童血清嗜酸性粒细胞趋化因子(Eotaxin)水平。结果：哮喘急性发作期组及慢性持续期组较正常对照组血清Eotaxin水平明显升高(P＜0.01)，哮喘急性发作期组及慢性持续期组血清Eotaxin水平与外周血嗜酸性粒细胞(Eos)记数、24 h PEF变异率(PEF%)呈正相关，与FEV1占预计值的百分比(FEV1%)呈负相关。结论：血清Eotaxin在儿童支气管哮喘致病过程中发挥重要作用，并与哮喘严重程度以及慢性持续状态有关，针对Eotaxin治疗有可能会开辟哮喘治疗的新方向。
목적：탐토혈청기산성립세포추화인자재인동지기관효천환자중적변화급의의。방법：응용ELISA법측정44례인동지기관효천이급37례정상인동혈청기산성립세포추화인자(Eotaxin)수평。결과：효천급성발작기조급만성지속기조교정상대조조혈청Eotaxin수평명현승고(P＜0.01)，효천급성발작기조급만성지속기조혈청Eotaxin수평여외주혈기산성립세포(Eos)기수、24 h PEF변이솔(PEF%)정정상관，여FEV1점예계치적백분비(FEV1%)정부상관。결론：혈청Eotaxin재인동지기관효천치병과정중발휘중요작용，병여효천엄중정도이급만성지속상태유관，침대Eotaxin치료유가능회개벽효천치료적신방향。
Objective:To explore the changes of eotaxin in serum of patients with bronchial asthma in children and its clinical significance.Methods:ELISA method was used to measure the level of eotaxin in serum of 44 cases of bronchial asthma in children and 37 normal children.Results:In the asthma acute stage group and the chronic persistent period group,compared with the normal control group,the serum level of eotaxin was significantly increased(P<0.01).In the asthma acute stage group and the chronic persistent period group,the level of serum eotaxin was positively correlated with eosinophils count in peripheral blood and 24 hours of PEF mutation rate(PEF%),and it was negatively related with FEV1 percentage of predicted value(FEV1%).Conclusion:The serum levels of eotaxin may play an important role in the pathogenesis of bronchial asthma in children.It was related to the severity of asthma and chronic persistent state.Treatment for eotaxin may open up new directions for asthma therapy.