CAJ | 학술논문

日益严重的细菌耐药性有可能使人类重回前抗生素时代。细菌的耐药机理多样，深入研究细菌的耐药性形成机理有助于开发控制耐药细菌感染的新措施。表观遗传和蛋白质翻译后修饰在细胞代谢、信号转导、蛋白质降解、调控DNA复制、应激反应等方面都具有重要作用。近年来研究表明表观遗传和蛋白质翻译后修饰在细菌耐药中也扮演着重要的角色。本文总结了DNA甲基化、调控型RNAs等表观遗传因素和磷酸化、琥珀酰基化等蛋白质翻译后修饰因素在细菌耐药性中的调控作用，以期为抗生素靶标选择和抗生素开发设计提供新思路。
일익엄중적세균내약성유가능사인류중회전항생소시대。세균적내약궤리다양，심입연구세균적내약성형성궤리유조우개발공제내약세균감염적신조시。표관유전화단백질번역후수식재세포대사、신호전도、단백질강해、조공DNA복제、응격반응등방면도구유중요작용。근년래연구표명표관유전화단백질번역후수식재세균내약중야분연착중요적각색。본문총결료DNA갑기화、조공형RNAs등표관유전인소화린산화、호박선기화등단백질번역후수식인소재세균내약성중적조공작용，이기위항생소파표선택화항생소개발설계제공신사로。
The increasing antibiotic resistance is now threatening to take us back to a pre-antibiotic era. Bacteria have evolved diverse resistance mechanisms, on which in-depth research could help the development of new strate-gies to control antibiotic-resistant infections. Epigenetic alterations and protein post-translational modifications (PTMs) play important roles in multiple cellular processes such as metabolism, signal transduction, protein degrada-tion, DNA replication regulation and stress response. Recent studies demonstrated that epigenetics and PTMs also play vital roles in bacterial antibiotic resistance. In this review, we summarize the regulatory roles of epigenetic fac-tors including DNA methylation and regulatory RNAs as well as PTMs such as phosphorylation and succinylation in bacterial antibiotic resistance, which may provide innovative perspectives on selecting antibacterial targets and developing antibiotics.