CAJ | 학술논문

最新研究表明，RNA之间可以通过竞争结合共同的microRNA反应元件(microRNA response element, MRE)实现相互调节，这种调控模式构成竞争性内源RNA(Competing endogenous RNA, ceRNA)。已发现的ceRNA包括蛋白编码mRNA和非编码RNA，其中后者包括假基因转录物、长链非编码RNA(Long non-coding RNA, lncRNA)、环状RNA(Circular RNA, circRNA)等。文章主要从ceRNA分类的角度，阐述各类ceRNA构成的调控网络发挥的生物学功能在病理和生理相关过程中的作用，以及可能影响ceRNA调控有效性的因素。
최신연구표명，RNA지간가이통과경쟁결합공동적microRNA반응원건(microRNA response element, MRE)실현상호조절，저충조공모식구성경쟁성내원RNA(Competing endogenous RNA, ceRNA)。이발현적ceRNA포괄단백편마mRNA화비편마RNA，기중후자포괄가기인전록물、장련비편마RNA(Long non-coding RNA, lncRNA)、배상RNA(Circular RNA, circRNA)등。문장주요종ceRNA분류적각도，천술각류ceRNA구성적조공망락발휘적생물학공능재병리화생리상관과정중적작용，이급가능영향ceRNA조공유효성적인소。
Recent studies demonstrate that RNA species could regulate each other by competing for shared microRNA response elements (MREs). This regulatory model is called competing endogenous RNA (ceRNA). Cur-rently, the identified ceRNAs cover coding and non-coding RNAs. The latter includes pseudogene transcripts, long non-coding RNAs (lncRNAs), circular RNAs (circRNAs) and so on. In this review, we summarize the biological functions of regulatory networks consisting of various types of ceRNAs and their roles in the pathological and physi-ological processes. Additionally, several factors that may regulate ceRNAs were discussed.