CAJ | 학술논문

目的：探讨预混胰岛素血糖控制不佳的超重或肥胖2型糖尿病患者加用利拉鲁肽后的临床疗效。方法：收治预混胰岛素血糖控制不佳的超重或肥胖2型糖尿病患者80例，随机分为观察组和对照组，各40例。所有患者均按照糖尿病食谱进行饮食指导，对照组给予二甲双胍、门冬胰岛素30注射液。观察组在对照组的基础上加用利拉鲁肽。结果：观察组血糖恢复正常时间短于对照组(P＜0.05)；两组治疗后比较，空腹血糖、餐后2 h血糖、糖化血红蛋白、胰岛素敏感指数、体重指数差异均有统计学意义(P＜0.05)；观察组发生不良反应少于对照组(P＜0.05)。结论：预混胰岛素血糖控制不佳的超重或肥胖2型糖尿病患者，加用利拉鲁肽降糖作用显著，减重作用明显，不良反应少。
목적：탐토예혼이도소혈당공제불가적초중혹비반2형당뇨병환자가용리랍로태후적림상료효。방법：수치예혼이도소혈당공제불가적초중혹비반2형당뇨병환자80례，수궤분위관찰조화대조조，각40례。소유환자균안조당뇨병식보진행음식지도，대조조급여이갑쌍고、문동이도소30주사액。관찰조재대조조적기출상가용리랍로태。결과：관찰조혈당회복정상시간단우대조조(P＜0.05)；량조치료후비교，공복혈당、찬후2 h혈당、당화혈홍단백、이도소민감지수、체중지수차이균유통계학의의(P＜0.05)；관찰조발생불량반응소우대조조(P＜0.05)。결론：예혼이도소혈당공제불가적초중혹비반2형당뇨병환자，가용리랍로태강당작용현저，감중작용명현，불량반응소。
Objective:To discuss the clinical curative effect of premixed insulin poor glycemic control overweight or obese patients with type 2 diabetes plus liraglutide.Methods:80 patients with premixed insulin poor glycemic control overweight or obese patients with type 2 diabetes were selected.They were randomly divided into observation group and control group, each of 40 cases.All patients were given diet guidance according to the diabetic diet.The control group were given metformin,insulin aspart 30 injection.The observation group were given liraglutide on the basis of the control group.Results:The time of blood sugar back to normal of the observation group was less than that of the control group(P<0.05).After treatment,the differences of fasting blood glucose,postprandial 2 h blood glucose,glycated hemoglobin,insulin sensitive index,body mass index of two groups were statistically significant(P<0.05);the adverse reactions of the observation group was less than that of the control group(P<0.05). Conclusion:The clinical curative effect of premixed insulin poor glycemic control overweight or obese patients with type 2 diabetes plus liraglutide is outstanding,significant weight loss,with less adverse reactions occur.