中国社区医师
中國社區醫師
중국사구의사
Chinese Community Doctors
2015年
23期
11-12
,共2页
复方甲硝唑泡腾片%盐酸土霉素%药效学研究
複方甲硝唑泡騰片%鹽痠土黴素%藥效學研究
복방갑초서포등편%염산토매소%약효학연구
Compound metronidazole effervesecent tablets%Oxytetracycline hydrochloride%Pharmacodynamic study
目的：探讨复方甲硝唑泡腾片的制备工艺以及药效学。方法：通过正交实验法优选复方甲硝唑泡腾片的制作处方，处方为甲硝唑、盐酸土霉素、酸源、碱源以及其他辅料，采用无水乙醇制粒、低温干燥、内外联合添加崩解剂后压片。并对制作的甲硝唑泡腾片药效进行检验。结果：复方甲硝唑泡腾片药液的培养基均无浑浊现象，单纯甲硝唑培养基存在不同程度的浑浊现象，盐酸土霉素培养基同样存在不同程度的浑浊现象。结论：按本法制备的复方甲硝唑泡腾片方法简便，且抑菌效果显著。
目的：探討複方甲硝唑泡騰片的製備工藝以及藥效學。方法：通過正交實驗法優選複方甲硝唑泡騰片的製作處方，處方為甲硝唑、鹽痠土黴素、痠源、堿源以及其他輔料，採用無水乙醇製粒、低溫榦燥、內外聯閤添加崩解劑後壓片。併對製作的甲硝唑泡騰片藥效進行檢驗。結果：複方甲硝唑泡騰片藥液的培養基均無渾濁現象，單純甲硝唑培養基存在不同程度的渾濁現象，鹽痠土黴素培養基同樣存在不同程度的渾濁現象。結論：按本法製備的複方甲硝唑泡騰片方法簡便，且抑菌效果顯著。
목적：탐토복방갑초서포등편적제비공예이급약효학。방법：통과정교실험법우선복방갑초서포등편적제작처방，처방위갑초서、염산토매소、산원、감원이급기타보료，채용무수을순제립、저온간조、내외연합첨가붕해제후압편。병대제작적갑초서포등편약효진행검험。결과：복방갑초서포등편약액적배양기균무혼탁현상，단순갑초서배양기존재불동정도적혼탁현상，염산토매소배양기동양존재불동정도적혼탁현상。결론：안본법제비적복방갑초서포등편방법간편，차억균효과현저。
Objective:To explore the preparation process and pharmacodynamics of compound metronidazole effervesecent tablets. Methods:We preferred making prescription of compound metronidazole effervesecent tablets by orthogonal experimental method, the prescription included metronidazole,oxytetracycline hydrochloride,acid source,alkali source and other accessories,we used anhydrous ethanol granulation,low temperature drying,and combined inside and outside for adding disintegrating agent and tablet compressing.We examined the efficacy of the metronidazole effervesecent tablets.Results:There was no turbidity in culture media for compound metronidazole effervesecent tablets soup,there was different degree turbidity in culture media for pure metronidazole,there was different degree turbidity in culture media for oxytetracycline hydrochloride.Conclusion:The method for development of compound metronidazole effervesecent tablets was simple,and the antibacterial effect was significant.
