CAJ | 학술논문

目的：系统评价广西地区中西医结合治疗慢性心力衰竭的临床疗效。方法检索CNKI、VIP、万方数据库和Pubmed、the Cochrane Library 数据库，查找广西地区中西医结合治疗慢性心力衰竭的随机对照试验和半随机对照试验，采用Cochrane 方法评价每篇文献质量，然后采用RevMan软件进行Meta分析。结果共纳入19个试验。 Meta分析结果：治疗组左室射血分数、每搏量、患者6 min步行试验均较对照组显著改善（P均＜0．01），治疗组总有效率明显高于对照组（P＜0．01）。结论现有证据表明在常规西药基础上加用中医药治疗慢性心力衰竭具有较好的疗效。但目前的Meta分析纳入研究质量较低，结果有待进一步验证，真正评价中西医治疗慢性心力衰竭的疗效还需要大样本、多中心的严格设计的高质量随机对照试验。
목적：계통평개엄서지구중서의결합치료만성심력쇠갈적림상료효。방법검색CNKI、VIP、만방수거고화Pubmed、the Cochrane Library 수거고，사조엄서지구중서의결합치료만성심력쇠갈적수궤대조시험화반수궤대조시험，채용Cochrane 방법평개매편문헌질량，연후채용RevMan연건진행Meta분석。결과공납입19개시험。 Meta분석결과：치료조좌실사혈분수、매박량、환자6 min보행시험균교대조조현저개선（P균＜0．01），치료조총유효솔명현고우대조조（P＜0．01）。결론현유증거표명재상규서약기출상가용중의약치료만성심력쇠갈구유교호적료효。단목전적Meta분석납입연구질량교저，결과유대진일보험증，진정평개중서의치료만성심력쇠갈적료효환수요대양본、다중심적엄격설계적고질량수궤대조시험。
Objective It is to systematically evaluate the effectiveness of combination of traditional Chinese medicine and western medicine for chronic heart failure (CHF).Methods The databases including CNKI , VIP, Wanfang, Pubmed, the Co-chrane Library were electronically searched to fine randomized controlled trial ( RCT) and quasi-RCTs on the combination of traditional Chinese medicine and western medicine for CHF in Guangxi area .The quality of each trial was assessed according to Cochrane methods .Then Meta-analysis was performed using RevMan soft ware .Results 19 trials were included .The re-sults of Meta-analysis showed that:compared with control group, in treatment group LVEF, CO and 6MWT were significantly improved (P<0.01) and the total effective rate was much higher .Conclusion Current evidence suggests that adding with tra-ditional Chinese medicine on the basis of therapy with normal western medicine is effective in treating CHF .However , the strength of evidence is affected by poor methodological quality of the included studies .High-quality trials with large sample size and multicenter are needed to verify its clinical effects .