CAJ | 학술논문

目的：探讨采用博利康尼片和射干麻黄散联合治疗小儿哮喘急性期寒哮证的临床效果。方法选取2013年5月至2014年5月到中山市陈星海医院儿科和贵阳市第一人民医院儿科进行小儿哮喘急性期寒哮证治疗的患儿80例，按照其入院顺序分为观察组和对照组各40例。两组患儿均服用西药博利康尼片治疗，观察组在此基础上给予射干麻黄散治疗。以7 d为1个疗程，观察两组患儿治疗1个疗程后的最大呼气流量（PEF）、最大呼气中段流量（MMEF）75/25、嗜酸性粒细胞绝对值及用药的生效时间差异，比较两组患儿采用不同药物治疗的临床效果。结果观察组患儿治疗后的PEF、MMEF75/25较治疗前有明显增加，且治疗后上述指标大于对照组，差异均有统计学意义（P＜0.01）；观察组患儿治疗后的嗜酸性粒细胞绝对值小于对照组，差异有统计学意义（P＜0.05）；观察组患儿用药后生效时间小于48 h时的生效率[80.0%（32/40）]高于对照组[47.5%（19/40）]，且观察组患儿的总有效率[90.0%（36/40）]高于对照组[77.5%（31/40）]，差异均有统计学意义（P＜0.01）。结论对哮喘急性期寒哮证患儿采用博利康尼片和射干麻黄散进行联合治疗临床效果显著，值得推广应用。
목적：탐토채용박리강니편화사간마황산연합치료소인효천급성기한효증적림상효과。방법선취2013년5월지2014년5월도중산시진성해의원인과화귀양시제일인민의원인과진행소인효천급성기한효증치료적환인80례，안조기입원순서분위관찰조화대조조각40례。량조환인균복용서약박리강니편치료，관찰조재차기출상급여사간마황산치료。이7 d위1개료정，관찰량조환인치료1개료정후적최대호기류량（PEF）、최대호기중단류량（MMEF）75/25、기산성립세포절대치급용약적생효시간차이，비교량조환인채용불동약물치료적림상효과。결과관찰조환인치료후적PEF、MMEF75/25교치료전유명현증가，차치료후상술지표대우대조조，차이균유통계학의의（P＜0.01）；관찰조환인치료후적기산성립세포절대치소우대조조，차이유통계학의의（P＜0.05）；관찰조환인용약후생효시간소우48 h시적생효솔[80.0%（32/40）]고우대조조[47.5%（19/40）]，차관찰조환인적총유효솔[90.0%（36/40）]고우대조조[77.5%（31/40）]，차이균유통계학의의（P＜0.01）。결론대효천급성기한효증환인채용박리강니편화사간마황산진행연합치료림상효과현저，치득추엄응용。
Objective To investigate the clinical effect of Bricanyl Tablets combined with Belamcandae and Ephedra Powder in the treatment of cold syndrome of children acute asthma. Methods 80 cases of cold syndrome of children acute asth-ma in our hospitals from May 2013 to May 2014 were collected and divided into the observation group and control group according to the admission sequence,40 cases in each group. The two groups all took the Western medicine Bricanyl Tablets,while on this basis the observation group was given the therapy of Belamcandae and Ephedra Powder ,with 7 d as a course of treatment. The dif-ferences of PEF,MMEF75/25,eosinophil absolute value and the effective onset time after 1 course of treatment in the two groups were observed. The clinical effects of the different medications were compared between the two groups. Results PEF and MMEF75/25 after treatment in the observation group were significantly increased compared with before treatment ,moreover the above indexes after treatment in the observation group were significantly greater than those in the control group ,the differences were statistically significant(P<0.01);the eosinophil absolute value after treatment in the observation group was less than that in the control group, the difference was statistically significant(P<0.05);the effective rate of the effective onset time less than 48 h after medication in the observation group was 80.0%(32/40),which was higher than 47.5%(19/40) in the control group,moreover the total effective rate in the observation group was 90.0%(36/40),which was significantly higher than 77.5%(31/40) in the control group,the difference was statistically significant(P<0.01). Conclusion Bricanyl Tablets combined with Belamcandae and Ephedra Powder has significantly clinical effect in treating cold syndrome of children acute asthma and is worthy to be popularized in clin ic.