中国社区医师
中國社區醫師
중국사구의사
Chinese Community Doctors
2015年
26期
5-5,9
,共2页
非酒精性脂肪性肝病%非酒精性脂肪肝炎%动物模型
非酒精性脂肪性肝病%非酒精性脂肪肝炎%動物模型
비주정성지방성간병%비주정성지방간염%동물모형
Nonalcoholic fatty liver disease%Nonalcoholic fatty hepatitis%Animal model
非酒精性脂肪性肝病是在未过量饮酒的情况下,以肝细胞脂肪变性和脂质贮积为特征的一系列临床病理综合征。至今有很多NAFLD动物模型,但仍缺乏能涵盖人类整个疾病谱的单一动物模型。本文主要讲述基因敲除或基因突变模型,营养、药物或毒物诱发模型,复合模型这3类模型以及它们的优缺点,以便于研究者的选择。
非酒精性脂肪性肝病是在未過量飲酒的情況下,以肝細胞脂肪變性和脂質貯積為特徵的一繫列臨床病理綜閤徵。至今有很多NAFLD動物模型,但仍缺乏能涵蓋人類整箇疾病譜的單一動物模型。本文主要講述基因敲除或基因突變模型,營養、藥物或毒物誘髮模型,複閤模型這3類模型以及它們的優缺點,以便于研究者的選擇。
비주정성지방성간병시재미과량음주적정황하,이간세포지방변성화지질저적위특정적일계렬림상병리종합정。지금유흔다NAFLD동물모형,단잉결핍능함개인류정개질병보적단일동물모형。본문주요강술기인고제혹기인돌변모형,영양、약물혹독물유발모형,복합모형저3류모형이급타문적우결점,이편우연구자적선택。
Nonalcoholic fatty liver disease is a series of clinical pathological syndrome with liver steatosis and lipid storage characteristics,under the condition of not excessive drinking.So far,there are many NAFLD animal models,but still lack of a single animal model that can cover the entire spectrum of human disease.In this paper,we mainly descripted 3 models,including gene knockout or gene mutation model,nutrition,drug or poison induced model,and complex model,and we also tell about the advantages and disadvantages of those models,in order to help researchers to choose.